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Titolo:
Role of cholecystokinin receptors in induction of an antinociception in hot-plate test
Autore:
Rezayat, M; Rahnavard, A; Zarrindast, MR;
Indirizzi:
Tehran Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran Tehran Univ MedSci Tehran Iran , Sch Med, Dept Pharmacol, Tehran, Iran
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 2, volume: 87, anno: 2000,
pagine: 58 - 62
SICI:
0901-9928(200008)87:2<58:ROCRII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE ANALGESIA; ANTAGONIST L-364,718; OCTAPEPTIDE CCK-8; BETA-ENDORPHIN; B RECEPTOR; CERULEIN; RAT; TOLERANCE; MICE; PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Zarrindast, MR Tehran Univ Med Sci, Sch Med, Dept Pharmacol, POB 13145-784, Tehran, Iran Tehran Univ Med Sci POB 13145-784 Tehran Iran ehran, Iran
Citazione:
M. Rezayat et al., "Role of cholecystokinin receptors in induction of an antinociception in hot-plate test", PHARM TOX, 87(2), 2000, pp. 58-62

Abstract

In the present study, the antinociceptive effect of cholecystokinin receptor agonists in the hot-plate test in mice has been evaluated. Subcutaneous administration of cholecystokinin octapeptide (cholecystokinin-8; 0.001, 0.005, 0.01, 0.05, and 0.1 mg/kg), unsulfated cholecystokinin octapeptide (cholecystokinin-8U; 0.1 mg/kg) or caerulein (0.25 mg/kg) produced antinociception. Administration of the cholecystokinin tetrapeptide (cholecystokinin-4; 0.25, 0.5 and 1.0 mg/kg) had no effect in the hot-plate test. Subcutaneous injection of the selective cholecystokinin receptor antagonists, MK-329 (0.125, 0.25 and 0.5 mg/kg) or L-365,260 (0.125, 0.25 and 0.5 mg/kg), produced no antinociceptive response. When the animals were pretreated with the cholecystokinin receptor antagonists or naloxone (0.5 and 1 mg/kg), a significant decrease in the antinociceptive response induced by cholecystokinin-8and caerulein was obtained. The results indicate that single administration of cholecystokinin receptor agonists could produce an antinociceptive effect which is probably mediated via cholecystokinin receptors. With respect to the results obtained from morphine and naloxone administration, it is concluded that there may be an interaction between cholecystokinin and opiatemechanisms.

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Documento generato il 04/12/20 alle ore 16:09:57