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Titolo:
Imaging Tc-99m-labeled FGF-1 targeting in rats
Autore:
Zinn, KR; Kelpke, S; Chaudhuri, TR; Sugg, T; Mountz, JM; Thompson, JA;
Indirizzi:
Univ Alabama, Dept Radiol, Div Nucl Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 v Nucl Med, Birmingham, AL 35294 USA Univ Alabama, Dept Surg, Div Transplantat, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ansplantat, Birmingham, AL 35294 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 4, volume: 27, anno: 2000,
pagine: 407 - 414
SICI:
0969-8051(200005)27:4<407:ITFTIR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; FACTOR-I; FACTOR FAMILY; RECEPTORS; IMMUNOLOCALIZATION; EXPRESSION; ANGIOGENESIS; REJECTION; SCAFFOLD; INJURY;
Keywords:
Tc-99m; imaging; FGF-1; growth factor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Zinn, KR Univ Alabama, Dept Radiol, Div Nucl Med, BDB Box 11,1808 7th Ave S, Birmingham, AL 35294 USA Univ Alabama BDB Box 11,1808 7th Ave S Birmingham AL USA 35294 SA
Citazione:
K.R. Zinn et al., "Imaging Tc-99m-labeled FGF-1 targeting in rats", NUCL MED BI, 27(4), 2000, pp. 407-414

Abstract

Recombinant human acidic fibroblast growth factor (FGF-1) was radiolabeledwith Tc-99m by the HYNIC method. The Tc-99m-FGF-1 retained its representative molecular mass, heparin affinity, cellular binding to both law (Kd = 9.5 nM) and high (Kd = 125 pM) affinity sites, and mitogenic activity. Gamma camera imaging after intravenous dosing in rats confirmed high liver and kidney binding. Heparin significantly decreased Tc-99m-FGF-1 liver uptake andincreased urinary excretion. These studies illustrate a new method for imaging FGF-1 targeting under various conditions. NUCL MED BIOL 27;4:407-414, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/08/20 alle ore 18:25:28