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Titolo:
Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation
Autore:
Poeggel, G; Haase, C; Gulyaeva, N; Braun, K;
Indirizzi:
Univ Leipzig, Inst Zool, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 Inst Zool, D-04103 Leipzig, Germany Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Dept Funct Biochem, Moscow 117865, Russia Russian Acad Sci Moscow Russia 117865 nct Biochem, Moscow 117865, Russia Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany Leibniz Inst NeurobiolMagdeburg Germany D-39118 9118 Magdeburg, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 99, anno: 2000,
pagine: 381 - 387
SICI:
0306-4522(2000)99:2<381:QCIRNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; NADPH-DIAPHORASE; WHITE-MATTER; POSTNATAL-DEVELOPMENT; CORTICAL DEVELOPMENT; PREFRONTAL CORTEX; CALRETININ-IMMUNOREACTIVITY; INTERSTITIAL NEURONS; ENDOTHELIAL-CELLS; NEGATIVE FEEDBACK;
Keywords:
emotional experience; brain maturation; limbic system; corpus callosum; precocious rodents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Poeggel, G Univ Leipzig, Inst Zool, Talstr 33, D-04103 Leipzig, Germany Univ Leipzig Talstr 33 Leipzig Germany D-04103 eipzig, Germany
Citazione:
G. Poeggel et al., "Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation", NEUROSCIENC, 99(2), 2000, pp. 381-387

Abstract

The influence of preweaning maternal separation and postweaning social isolation on the development of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase-reactive neurons in prefrontal cortical areas, in subdivisions of the nucleus accumbens and in the corpus callosum was quantitatively investigated in the precocious rodent Octodon degus. Forty five-day-old degus from three animal groups were compared: (i) degus that were reared under normal undisturbed social conditions; (ii) degus that were repeatedly separated from their mothers during the first three postnatal weeks and thereafter reared with their family; and (iii) degus that remained undisturbed with the family until weaning (postnatal day 21) and thereafter were reared in social isolation. Preweaning maternal separation led to a significant decrease in NADPH-diaphorase-containing neurons in the corpus callosumin both genders (down to 33%) compared with the social control group. No significant changes were found in the subregions of the medial prefrontal cortex and nucleus accumbens. Postweaning social isolation led to a reduced density of NADPH-diaphorase-containing neurons in the corpus callosum in both genders (down to 52%) compared with the social control group. Furthermore, in the precentral medial cortex of female pups, a significant reduction in NADPH-diaphorase-reactive neurons (down to 72%) was detectable. All otherregions of the medial prefrontal cortex and the nucleus accumbens remainedunchanged. The observed deprivation-induced changes may reflect either an excessive reduction in NADPH-diaphorase-positive neurons or a down-regulation of the enzyme in neurons that normally express it. Our results indicate a link between early adverse socio-emotional experience and the maturation of NADPH-reactive neurons. Further studies are required to analyse the functional implications of this experience-induced brain pathology. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:03:21