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Titolo:
Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration
Autore:
Bazyan, AS; Getsova, VM; Orlova, NV;
Indirizzi:
Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia Russian Acad Sci Moscow Russia rvous Act & Neurophysiol, Moscow, Russia
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 99, anno: 2000,
pagine: 279 - 288
SICI:
0306-4522(2000)99:2<279:HCCITR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DAY-OLD CHICKS; DOPAMINE AUTORECEPTORS MODULATE; MEDIAL PREFRONTAL CORTEX; D-ASPARTATE RECEPTORS; MESSENGER-RNA LEVELS; TYROSINE-HYDROXYLASE; CAUDATE-PUTAMEN; GENE-EXPRESSION; ACUTE METHAMPHETAMINE;
Keywords:
long-term potentiation; catecholamine autoreceptors; heteroreceptors; learning; consolidation; retrieval;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Bazyan, AS Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia Russian Acad Sci Moscow Russia Neurophysiol, Moscow, Russia
Citazione:
A.S. Bazyan et al., "Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration", NEUROSCIENC, 99(2), 2000, pp. 279-288

Abstract

Haloperidol, a non-selective D-2 dopamine antagonist, both in vitro (1 mu M) and in vivo (2.5 mg/kg i.p.), induced a longterm potentiation of K+-induced Ca2+-dependent release of endogenous noradrenaline and dopamine in rat brain cortical slices, by increasing the content of noradrenaline and dopamine known to be controlled by dopamine auto- and heteroreceptors. Haloperidol administration (2.5 mg/kg i.p.) evoked catalepsy and increased the content of noradrenaline and dopamine in the same structures of the brain. Haloperidol catalepsy consolidated without any additional learning and could be retrieved up to two weeks later by placing the animals in the test box. Thecatalepsy is disordered and retrieved only in the test box. The catalepsy was more intense on day 14 than on day 7. Injection of haloperidol immediately after conditioning evened the reflex retrieval on the following days. Moreover, learning increased the intensity of catalepsy in animals tested onthe day of injection. Repeated testing of the reflex on the following daysled to specific modifications of catalepsy retrieval. Pre-conditioned ratsexhibited maximal catalepsy when tested immediately after being placed in the test box. These results suggest that both the processes of long-term potentiation and catalepsy consolidation are mediated by the same type of receptors, long-term modulation-inducing receptors. Endogenous neuromodulators, acting non-specifically or diffusely via their respective long-term modulation-inducing receptors, can initiate and consolidate generalized states which form thebasis for emotional and motivational states. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:49:58