Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Context-specific enhancement of glutamate transmission by cocaine
Autore:
Bell, K; Duffy, P; Kalivas, PW;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 335 - 344
SICI:
0893-133X(200009)23:3<335:CEOGTB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MEDIAL PREFRONTAL CORTEX; IBOTENIC ACID LESIONS; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; EXTRACELLULAR GLUTAMATE; AMPHETAMINE; DOPAMINE; EXPRESSION; BRAIN;
Keywords:
glutamate; cocaine; sensitization; nucleus accumbens; AMPA; dialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kalivas, PW Med Univ S Carolina, Dept Physiol & Neurosci, 167 Ashley Ave,Suite 607,POB250677, Charleston, SC 29425 USA Med Univ S Carolina 167 AshleyAve,Suite 607,POB 250677 Charleston SC USA 29425
Citazione:
K. Bell et al., "Context-specific enhancement of glutamate transmission by cocaine", NEUROPSYCH, 23(3), 2000, pp. 335-344

Abstract

The repeated injection of cocaine causes an increase in the capacity of a subsequent acute injection to elevate extracellular glutamate levels in thenucleus accumbens, and the present study sought to determine if the elevation in extracellular glutamate is regulated by the pairing of environmentalstimuli with drug administration. Three treatment groups were injected daily for seven days with saline or cocaine (15 mg/kg, ip); 1) injection of saline in the home cage, 2) injection of cocaine in the home cage (cocaine-unpaired), and 3) injection of cocaine in the test apparatus (cocaine-paired). Three weeks following the last daily injection dialysis probes were placed into the nucleus accumbens and all rats were injected with saline followed by cocaine. Basal levels of extracellular glutamate were significantly reduced in the cocaine-paired treatment group. Moreover, only in the cocaine-paired group did the cocaine injection elevate extracellular glutamate. Repeated administration of cocaine also produces an enduring increase in the motor stimulant response to an acute cocaine injection and it was previouslyfound that administration of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainic acid glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione inhibited the sensitized, but not the acute motor, response to cocaine. In this study it was found that the motor stimulant response elicited by cocaine was blunted by pretreatment of the nucleus accumbens with 6-cyano-7-nitroquinoxaline-2,3-dione only in animals receiving daily cocaine injections in the paired environment. In contrast, the N-methyl-D-aspartate glutamate receptor antagonist R-(-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid did not significantly affect cocaine-induced motor activity in any treatment group. These data support a hypothesis that environmental stimuli previously associated with daily cocaine administrationcan modulate glutamate transmission in the nucleus accumbens in a manner affecting cocaine-induced behavior. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:40:52