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Titolo:
Buprenorphine-induced changes in mu-opioid receptor availability in male heroin-dependent volunteers: A preliminary study
Autore:
Zubieta, JK; Greenwald, MK; Lombardi, U; Woods, JH; Kilbourn, MR; Jewett, DM; Koeppe, RA; Schuster, CR; Johanson, CE;
Indirizzi:
Univ Michigan, Dept Neurosci, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 pt Neurosci, Ann Arbor, MI 48104 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 th Res Inst, Ann Arbor, MI 48104 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 pt Psychiat, Ann Arbor, MI 48104 USA Univ Michigan, Dept Internal Med, Div Nucl Med, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 iv Nucl Med, Ann Arbor, MI 48104 USA Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 t Pharmacol, Ann Arbor, MI 48104 USA Wayne State Univ, Res Div Subst Abuse, Dept Psychiat & Behav Neurosci, Detroit, MI USA Wayne State Univ Detroit MI USA ychiat & Behav Neurosci, Detroit, MI USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 326 - 334
SICI:
0893-133X(200009)23:3<326:BCIMRA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; FUNCTIONAL BRAIN IMAGES; OPERANT ANALYSIS; BINDING; HUMANS; PET; ADDICTION; BLOCKADE; COCAINE;
Keywords:
buprenorphine; positron emission tomography; opiates; opiate dependence; mu opioid receptors; carfentanil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Zubieta, JK Univ Michigan, Dept Neurosci, Neurosci Bldg,1103 E Huron St, Ann Arbor, MI48104 USA Univ Michigan Neurosci Bldg,1103 E Huron St Ann ArborMI USA 48104
Citazione:
J.K. Zubieta et al., "Buprenorphine-induced changes in mu-opioid receptor availability in male heroin-dependent volunteers: A preliminary study", NEUROPSYCH, 23(3), 2000, pp. 326-334

Abstract

A principle of opioid pharmacotherapy is that high medication doses shouldoccupy fractionally more opioid receptors that mediate heroin effects. In this preliminary study we examined in vivo mu opioid receptor (mu OR) binding in three healthy opioid-dependent volunteers during maintenance on 2 and16 mg sublingual buprenorphine (BUP) liquid, and after detoxification (0 mg) under double-blind, placebo-controlled conditions, and once in matched controls. Binding measures were obtained with the mu OR-selective radioligand [C-11]carfentanil (CFN) and PET 4 hrs after BUP administration. BUP induced dose-dependent reductions in mu OR availability, 36-50% at 2 mg and 79-95% at 16 mg relative to placebo. Heroin abusers also had greater mu OR binding potential in the inferofrontal cortex and anterior cingulate regions during placebo, compared to matched controls. Further studies are warranted to examine the relationship of mu OR availability with BUP therapeutic actions, and the clinical implications of increased mu OR binding during withdrawal. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

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Documento generato il 14/07/20 alle ore 18:44:58