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Titolo:
Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex
Autore:
Zhang, W; Perry, KW; Wong, DT; Potts, BD; Bao, JQ; Tollefson, GD; Bymaster, FP;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Div, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 Div, Indianapolis, IN 46285 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 250 - 262
SICI:
0893-133X(200009)23:3<250:SEOOAO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; FRONTAL-CORTEX; NUCLEUS-ACCUMBENS; SEROTONIN UPTAKE; RECEPTOR ANTAGONIST; UPTAKE INHIBITOR; INCREASES; SCHIZOPHRENIA; NORADRENALINE; SERTRALINE;
Keywords:
olanzapine; fluoxetine; depression; serotonin; dopamine; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bymaster, FP Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Neurosci Res Div, DC 0510,Indianapolis, IN 46285 USA Eli Lilly & Co DC 0510 IndianapolisIN USA 46285 IN 46285 USA
Citazione:
W. Zhang et al., "Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex", NEUROPSYCH, 23(3), 2000, pp. 250-262

Abstract

To understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (TRD), we studied the effects of olanzapine and other antipsychotics in combination with the selective serotonin uptake inhibitors fluoxetine or sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using microdialysis. The combination of olanzapine and fluoxetine produced robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the baseline, respectively, which were significantly greater than either drug alone. This combination produced a slightly smaller increase of serotonin ([5-HT](ex)) than fluoxetinealone. The combination (o)f clozapine or risperidone with fluoxetine produced less robust and persistent increases of [DA](ex) and [NE](ex). The combination of haloperidol or MDL 100907 with fluoxetine did not increase the monoamines more than fluoxetine alone. Olanzapine plus sertraline combination increased only [DA](ex). Therefore, the large, sustained increase of [DA](ex), [NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatmentwas unique and may contribute to the profound antidepressive effect of theolanzapine and fluoxetine therapy in TRD. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:06:28