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Titolo:
A meta-analysis of methylprednisolone in recovery from multiple sclerosis exacerbations
Autore:
Miller, DM; Weinstock-Guttman, B; Bethoux, F; Lee, JC; Beck, G; Block, V; Durelli, L; LaMantia, L; Barnes, D; Sellebjerg, F; Rudick, RA;
Indirizzi:
Cleveland Clin Fdn, IH Page Ctr Hlth Outcomes Res, Cleveland, OH 44195 USACleveland Clin Fdn Cleveland OH USA 44195 es Res, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Biostat & Epidemiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 demiol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Neurol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Neurol, Cleveland, OH 44195 USA SUNY Buffalo, Buffalo Gen Hosp, Dept Neurol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 osp, Dept Neurol, Buffalo, NY 14260 USA Univ Turin, Dipartimento Neurosci, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dipartimento Neurosci, Turin, Italy Inst Nazl Neurol C Besta, Milan, Italy Inst Nazl Neurol C Besta Milan Italy Nazl Neurol C Besta, Milan, Italy Atkinson Morleys Hosp, Dept Neurol, London, England Atkinson Morleys HospLondon England Hosp, Dept Neurol, London, England Univ Copenhagen, Glostrup Hosp, Dept Neurol, DK-1168 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-1168 , DK-1168 Copenhagen, Denmark
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 4, volume: 6, anno: 2000,
pagine: 267 - 273
SICI:
1352-4585(200008)6:4<267:AMOMIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE METHYLPREDNISOLONE; ACUTE OPTIC NEURITIS; DOUBLE-BLIND; INTRAVENOUS METHYLPREDNISOLONE; CONTROLLED TRIAL; RANDOMIZED TRIAL; ACUTE RELAPSES; DEXAMETHASONE; ACTH; MS;
Keywords:
multiple sclerosis; methylprednisolone; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, DM Cleveland Clin Fdn, IH Page Ctr Hlth Outcomes Res, U-10,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn U-10,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
D.M. Miller et al., "A meta-analysis of methylprednisolone in recovery from multiple sclerosis exacerbations", MULT SCLER, 6(4), 2000, pp. 267-273

Abstract

Despite recent advances in multiple sclerosis treatment, patients experience relapses for which standard treatment remains glucocorticosteroids (GCS). However, there is limited information comparing doses or routes of administration for different GCS types or the benefit of GCS compared to natural recovery. Currently, high dose (HD) methylprednisolone (MP) is the preferred therapy We conducted meta-analyses of published studies assessing MP at different doses and in comparison to other steroid products or no treatment Relevant studies were identified through predetermined processes and five articles met the inclusion criteria. Three studies compared HD MP to placebo; two studies compared the effect of HD MP and low dose (LD) MP; only one accepted report compared HD MP to another GCS. This report could not be included in a meta-analysis. The meta-analysis of HD MP vs placebo studies indicated a mean treatment difference of 0.76 in Expanded Disability Status Score (EDSS) changes from baseline. The meta-analysis of HD and LD MP demonstrated no difference in EDSS change. Despite these rather obvious findings, these meta-analyses have been valuable in identifying further research questions. We recommend studies to determine optimum benefit related to dosage, timing for starting therapy and the most appropriate GCS type. Given the advances in MS therapeutics these studies will have to include patients on additional disease modifying therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:50:20