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Titolo:
Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics
Autore:
Steegmaier, M; Oorschot, V; Klumperman, J; Scheller, RH;
Indirizzi:
Stanford Univ, Howard Hughes Med Inst, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 & Mol Physiol, Stanford, CA 94305 USA Univ Utrecht, Sch Med, Dept Cell Biol, Res Inst Biomembranes, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 8, volume: 11, anno: 2000,
pagine: 2719 - 2731
SICI:
1059-1524(200008)11:8<2719:S1IAIS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR TRANSPORT; GOLGI-APPARATUS; SYNAPTIC EXOCYTOSIS; VESICLE TRANSPORT; SNARE COMPLEX; RAT-LIVER; PROTEINS; ER; LOCALIZATION; TRAFFICKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Scheller, RH Stanford Univ, Howard Hughes Med Inst, Sch Med, Dept Cellular& Mol Physiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305, Stanford, CA 94305 USA
Citazione:
M. Steegmaier et al., "Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics", MOL BIOL CE, 11(8), 2000, pp. 2719-2731

Abstract

The endoplasmic reticulum (ER) consists of subcompartments that have distinct protein constituents, morphological appearances, and functions. To understand the mechanisms that regulate the intricate and dynamic organization of the endoplasmic reticulum, it is important to identify and characterize the molecular machinery involved in the assembly and maintenance of the different subcompartments. Here we report that syntaxin 17 is abundantly expressed in steroidogenic cell. types and specifically localizes to smooth membranes of the ER. By immunoprecipitation analyses, syntaxin 17 exists in complexes with a syntaxin regulatory protein, rsly1, and/or two intermediate compartment SNARE proteins, rsec22b and rbet1. Furthermore, we found that syntaxin 17 is anchored to the smooth endoplasmic reticulum through an unusual mechanism, requiring two adjacent hydrophobic domains near its carboxyl terminus. Converging lines of evidence indicate that syntaxin 17 functions in a vesicle-trafficking step to the smooth-surfaced tubular ER membranes that are abundant in steroidogenic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:43:58