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Titolo:
The antiestrogen ICI 182,780 inhibits proliferation of human breast cancercells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion
Autore:
Cicatiello, L; Addeo, R; Altucci, L; Petrizzi, VB; Boccia, V; Cancemi, M; Germano, D; Pacilio, C; Salzano, S; Bresciani, F; Weisz, A;
Indirizzi:
Univ Naples 2, Fac Med & Chirurg, Ist Patol Gen & Oncol, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 ol Gen & Oncol, I-80138 Naples, Italy Univ Naples Federico II, CNR, Ctr Endocrinol & Oncol Sperimentale, Naples,Italy Univ Naples Federico II Naples Italy & Oncol Sperimentale, Naples,Italy Univ Naples Federico II, CNR, Dipartimento Biol & Patol Cellulare & Mol L Calif, Naples, Italy Univ Naples Federico II Naples Italy ulare & Mol L Calif, Naples, Italy
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 165, anno: 2000,
pagine: 199 - 209
SICI:
0303-7207(20000725)165:1-2<199:TAI1IP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA PROTEIN-PHOSPHORYLATION; DEPENDENT KINASES; MITOGENIC STIMULATION; RAT UTERUS; ACTIVATION; TRANSCRIPTION; PROGRESSION; EXPRESSION; RECEPTOR; GROWTH;
Keywords:
antiestrogen; breast cancer; estrogen; cell cycle; cyclin; retinoblastoma protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Weisz, A Univ Naples 2, Fac Med & Chirurg, Ist Patol Gen & Oncol, Larghetto S Aniello & Caponapoli 2, I-80138 Naples, Italy Univ Naples 2 Larghetto SAniello & Caponapoli 2 Naples Italy I-80138
Citazione:
L. Cicatiello et al., "The antiestrogen ICI 182,780 inhibits proliferation of human breast cancercells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion", MOL C ENDOC, 165(1-2), 2000, pp. 199-209

Abstract

Antiestrogens are widely used for breast cancer treatment, where they act primarily by inhibiting the mitogenic action of estrogens on tumor cells. The effects of the pure antiestrogen ICI 182,780 on estrogen-regulated cell cycle phase-specific events were investigated here in synchronously cyclinghuman breast cancer (HBC) cells. In early G(1)-arrested MCF-7 or ZR-75.1 cells, 17 beta-estradiol (E2) induces rapid activation of the cyclin/Cdk/pRbpathway, as demonstrated by D-type G(1) cyclins accumulation during the first few hours of hormonal stimulation, followed by sequential accumulation of E, A and B1 cyclins and progressive pRb phosphorylation, as cells progress through the cell cycle. When added to quiescent cells together with E2, ICI 182,780 prevents all of the above hormonal effects. Interestingly, in mid-G(1) cells (2-8 h into estrogen stimulation) the antiestrogen causes rapid reversal of hormone-induced D-type cyclins accumulation and pRb phosphorylation, and still fully inhibits G(1)-S transition rate, while in late-G(1) cells it does not prevent S phase entry but still inhibits significantly DNA synthesis rate, S-phase cyclins accumulation and pRb hyperphosphorylation. These results indicate that pure antiestrogens prevent multiple estrogen-induced cell cycle-regulatory events, each timed to allow efficient G(1) completion, G(1)-S transition, DNA synthesis and cell cycle completion. (C)2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:34:42