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Titolo:
Symphony of rhythms in the Xenopus laevis retina
Autore:
Anderson, FE; Green, CB;
Indirizzi:
Univ Virginia, Dept Biol, NSF Ctr Biol Timing, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 5, volume: 50, anno: 2000,
pagine: 360 - 372
SICI:
1059-910X(20000901)50:5<360:SORITX>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN N-ACETYLTRANSFERASE; TRYPTOPHAN-HYDROXYLASE EXPRESSION; RECEPTOR-MEDIATED INHIBITION; D2 DOPAMINE RECEPTOR; CIRCADIAN CLOCK; CYCLIC-AMP; MELATONIN SYNTHESIS; PHOTORECEPTOR METABOLISM; DIFFERENTIAL DISPLAY; ROD PHOTORECEPTORS;
Keywords:
circadian; photoreceptor; nocturnin; clock; transgenic; melatonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Green, CB Univ Virginia, Dept Biol, NSF Ctr Biol Timing, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 sville, VA 22903 USA
Citazione:
F.E. Anderson e C.B. Green, "Symphony of rhythms in the Xenopus laevis retina", MICROSC RES, 50(5), 2000, pp. 360-372

Abstract

The photoreceptor layer in the retina of Xenopus laevis harbors a circadian clock. Many molecular components known to drive the molecular clock in other organisms have been identified in Xenopus, such as XClock, Xper2, and Xcrys, demonstrating phylogenetic conservation. This model system displays awide array of rhythms, including melatonin release, ERG rhythms, and retinomotor movements, suggesting that the ocular clock is important for proper retinal function. A flow-through culture system allows measurements of retinal rhythms such as melatonin release in vitro over time from a single eyecup. This system is suited for pharmacological perturbations of the clock, and has led to important observations regarding the circadian control of melatonin release, the roles of light and dopamine as entraining agents, and the circadian mechanisms regulating retinomotor movements. The development of a transgenic technique in Xenopus allows precise and reliable molecular perturbations. Since it is possible to follow rhythms in eyecups obtained from adults or tadpoles, the combination of the flow-through culture system and the transgenic technique leads to the fast generation of transgenic tadpoles to monitor the effects of molecular perturbations on the clock. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:23:05