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Titolo:
Noise in polymer gel measurements using MRI
Autore:
Low, DA; Markman, J; Dempsey, JF; Mutic, S; Oldham, M; Venkatesan, R; Haacke, EM; Purdy, JA;
Indirizzi:
Edward Mallinckrodt Inst Radiol, Div Radiat Oncol, St Louis, MO 63110 USA Edward Mallinckrodt Inst Radiol St Louis MO USA 63110 Louis, MO 63110 USA William Beaumont Hosp, Dept Radiat Oncol, Royal Oak, MI 48073 USA William Beaumont Hosp Royal Oak MI USA 48073 col, Royal Oak, MI 48073 USA Winpro GE Med Syst, Bangalore 560017, Karnataka, India Winpro GE Med SystBangalore Karnataka India 560017 017, Karnataka, India Magnet Resonance Imaging Inst Biomed Res, Brentwood, MO 63144 USA Magnet Resonance Imaging Inst Biomed Res Brentwood MO USA 63144 63144 USA
Titolo Testata:
MEDICAL PHYSICS
fascicolo: 8, volume: 27, anno: 2000,
pagine: 1814 - 1817
SICI:
0094-2405(200008)27:8<1814:NIPGMU>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; DOSIMETER;
Keywords:
BANG-2 polymerizing gel; dosimetry measurement noise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Low, DA Edward Mallinckrodt Inst Radiol, Div Radiat Oncol, 510 S Kingshighway Blvd, St Louis, MO 63110 USA Edward Mallinckrodt Inst Radiol 510 S Kingshighway Blvd St Louis MO USA 63110
Citazione:
D.A. Low et al., "Noise in polymer gel measurements using MRI", MED PHYS, 27(8), 2000, pp. 1814-1817

Abstract

With the development of conformal radiotherapy, particularly intensity modulated radiation therapy (IMRT), there is a clear need for multidimensionaldosimeters. A commercial polymerizing gel, BANG-2(R) gel (MGS Research, Inc., Guilford, CT), has recently been developed that shows potential as a multi-dimensional dosimeter. This study investigates and characterizes the noise and magnetic resonance (MR) artifacts from imaging BANG-2 gels. Seven cylindrical vials (4 cm diam, 20 cm length) were irradiated end on in a water bath and read using MRI (B-0 = 1.5 T, TE=20 ms/100 ms, TR=3000 ms). The gel calibration compared the measured depth-dose distributions in water against the change in solvent-proton R-2 relaxivity of the gel. A larger vial (13 cm diam, 14 cm length) was also irradiated to test the calibration accuracy in a vial of sufficient volume for dose distribution measurements. The calibration curve proved accurate to within 1.3% in determining the depth dose measured by the larger vial. An investigation of the voxel-to-voxel (IXIX 3 mm(3)) noise and sensitivity response curve showed that the voxel-to-voxel variation dominated the dose measurement uncertainty. The voxel-to-voxel standard deviation ranged from 0.2 Gy for the unirradiated gel to 0.7 Gyat 20 Gy. Slice-to-slice R-2 magnitude deviations were also observed corresponding to 0.2 Gy. These variations limited the overall accuracy of the gel dose measurements and warrant an investigation of more accurate MR readout sequences. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)02508-6].

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Documento generato il 08/04/20 alle ore 08:19:07