Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1 beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge
Autore:
Connor, TJ; Kelly, JP; McGee, M; Leonard, BE;
Indirizzi:
Natl Univ Ireland, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Galway Ireland eland, Dept Pharmacol, Galway, Ireland
Titolo Testata:
LIFE SCIENCES
fascicolo: 13, volume: 67, anno: 2000,
pagine: 1601 - 1612
SICI:
0024-3205(20000818)67:13<1601:M(ESIB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; IMMUNE FUNCTION; IN-VIVO; RATS; PLASMA; BETA; INTERLEUKIN-1-BETA; GLUCOCORTICOIDS; CORTICOSTERONE;
Keywords:
cytokine; immunity; in vivo; immune challenge; IL-1 beta; LPS; macrophage; MDMA; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Connor, TJ Natl Univ Ireland, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Galway Ireland Pharmacol, Galway, Ireland
Citazione:
T.J. Connor et al., "Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1 beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge", LIFE SCI, 67(13), 2000, pp. 1601-1612

Abstract

In this study we examined the effects of methylenedioxymethamphetamine (MDMA) administration on responsiveness to an in vivo immune challenge with lipopolysaccharide (LPS; 100 mu g/kg; i.p.). LPS produced an increase in circulating IL-1 beta and TNF-alpha in control animals. MDMA (20 mg/kg; i.p.) significantly impaired LPS-induced IL-1 beta and TNF-alpha secretion. The suppressive effect of MDMA on IL-1 beta secretion was transient and returned to control levels within 3 hours of administration. In contrast, the MDMA-induced suppression of TNF-alpha secretion was evident for up to 12 hours following administration. In a second study we examined the effect of cu-administration of MDMA (5, 10 and 20 mg/kg; i.p.) on LPS-induced IL-1 beta and TNF-alpha secretion, and demonstrated that all three doses potently suppressed LPS-induced TNF-alpha secretion, but only MDMA 10 and 20 mg/kg suppressed LPS-induced IL-1 beta secretion. In addition, serum MDMA concentrations displayed a dose-dependent increase, with the concentrations achieved following administration of 5 and 10 mg/kg being in the range reported in human MDMA abusers. In order to examine the possibility that the suppressive effect of MDMA on IL-1 beta and TNF-alpha could be due to a direct effect of the drug on immune cells, the effect of in vitro exposure to MDMA on IL-1 beta and TNF-alpha production in LPS-stimulated diluted whole blood was evaluated. However IL-1 beta or TNF-alpha production were not altered by in vitroexposure to MDMA. in conclusion, these data demonstrate that acute MDMA administration impairs IL-1 beta and TNF-alpha secretion following an in vivoLPS challenge, and that TNF-alpha is more sensitive to the suppressive effects of MDMA than is IL-1 beta. However the suppressive effect of MDMA on IL-1 beta and TNF-alpha could not be attributed to a direct effect on immunecells. The relevance of these findings to MDMA-induced immunomodulation isdiscussed. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 02:58:43