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Titolo:
DNA vaccines for influenza virus: Differential effects of maternal antibody on immune responses to hemagglutinin and nucleoprotein
Autore:
Pertmer, TM; Oran, AE; Moser, JM; Madorin, CA; Robinson, HL;
Indirizzi:
Emory Univ, Yerkes Primate Res Ctr, Div Microbiol & Immunol, Atlanta, GA 30329 USA Emory Univ Atlanta GA USA 30329 icrobiol & Immunol, Atlanta, GA 30329 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 17, volume: 74, anno: 2000,
pagine: 7787 - 7793
SICI:
0022-538X(200009)74:17<7787:DVFIVD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAL PROTEIN; ENHANCED PROTECTION; PSEUDORABIES VIRUS; PLASMID DNA; T-CELLS; IMMUNIZATION; GENE; GLYCOPROTEIN; ADENOVIRUS; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, HL Emory Univ, Yerkes Primate Res Ctr, Div Microbiol & Immunol, 954 Gatewood Rd NE, Atlanta, GA 30329 USA Emory Univ 954 Gatewood Rd NE Atlanta GA USA 30329 30329 USA
Citazione:
T.M. Pertmer et al., "DNA vaccines for influenza virus: Differential effects of maternal antibody on immune responses to hemagglutinin and nucleoprotein", J VIROLOGY, 74(17), 2000, pp. 7787-7793

Abstract

Maternal antibody is the major form of protection from disease in early life when the neonatal immune system is still immature; however, the presenceof maternal antibody also interferes with active immunization, placing infants at risk for severe bacterial and viral infection. We tested the ability of intramuscular and gene gun immunization with DNA expressing influenza virus hemagglutinin (HA) and nucleoprotein (NP) to raise protective humoraland cellular responses in the presence or absence of maternal antibody. Neonatal mice born to influenza virus-immune mothers raised full antibody responses to NP but failed to generate antibody responses to HA. In contrast, the presence of maternal antibody did not affect the generation of long-lived CD8(+) T-cell responses to both HA and NP. Thus, maternal antibody did not affect cell-mediated responses but did affect humoral responses, with the ability to limit the antibody response correlating with whether the DNA-expressed immunogen was localized in the plasma membrane or within the cell.

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Documento generato il 01/12/20 alle ore 08:03:24