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Titolo:
Antibodies to Borna disease virus in infected adult rats: An early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells
Autore:
Watanabe, M; Kobayashi, T; Tomonaga, K; Ikuta, K;
Indirizzi:
Osaka Univ, Res Inst Microbial Dis, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF VETERINARY MEDICAL SCIENCE
fascicolo: 7, volume: 62, anno: 2000,
pagine: 775 - 778
SICI:
0916-7250(200007)62:7<775:ATBDVI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
P/C MESSENGER-RNA; SENDAI VIRUS; Y-PROTEINS; NUCLEOPROTEIN; GLYCOPROTEIN; INITIATION;
Keywords:
animal brain; antibody; Borna disease virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tomonaga, K Osaka Univ, Res Inst Microbial Dis, Dept Virol, 3-1 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 3-1 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
M. Watanabe et al., "Antibodies to Borna disease virus in infected adult rats: An early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells", J VET MED S, 62(7), 2000, pp. 775-778

Abstract

The time course for appearance of antibodies to Boma disease virus (BDV) major antigens, p40, p24, pls and p10 were investigated in BDV-inoculated adult rats by Western blotting. Anti-p10 antibodies were detected in sera as early as anti-p40 and -p24 antibodies at four or five weeks after inoculation. Furthermore, in addition to these major antigens of BDV, the rat serum could detect additional 80-, 58-, 43-, 20-, and I6-kDa proteins in BDV-infected cultured cells and/or animal brain cells by Western blot analysis. Of these proteins, the 20- and 16-kDa proteins were shown to be related to p24protein by their reactivity with anti-p24 monoclonal antibody. Interestingly, the 58- and 24-kDa were found only in BDV-infected animal brain cells but not in cultured cells. The results in this study could provide a useful information on the mechanism for the viral replication and pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:31:20