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Titolo:
DEMONSTRATION OF DECREASED POSTERIOR CINGULATE PERFUSION IN MILD ALZHEIMERS-DISEASE BY MEANS OF (H2O)-O-15 POSITRON EMISSION TOMOGRAPHY
Autore:
ISHII K; SASAKI M; YAMAJI S; SAKAMOTO S; KITAGAKI H; MORI E;
Indirizzi:
HYOGO INST AGING BRAIN & COGNIT DISORDERS,HI,ABCD,DIV PSYCHIAT RES,520 SAISHO KO HIMEJI HYOGO 670 JAPAN KOBE UNIV,SCH MED,DEPT RADIOL KOBE HYOGO 650 JAPAN HYOGO INST AGING BRAIN & COGNIT DISORDERS,HI,ABCD,DIV CLIN NEUROSCI HIMEJI HYOGO 670 JAPAN
Titolo Testata:
European journal of nuclear medicine
fascicolo: 6, volume: 24, anno: 1997,
pagine: 670 - 673
SICI:
0340-6997(1997)24:6<670:DODPCP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEMENTIA; PET;
Keywords:
POSITRON EMISSION TOMOGRAPHY; O-15 LABELED WATER; ALZHEIMERS DISEASE; CEREBRAL BLOOD FLOW; POSTERIOR CINGULATE GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
K. Ishii et al., "DEMONSTRATION OF DECREASED POSTERIOR CINGULATE PERFUSION IN MILD ALZHEIMERS-DISEASE BY MEANS OF (H2O)-O-15 POSITRON EMISSION TOMOGRAPHY", European journal of nuclear medicine, 24(6), 1997, pp. 670-673

Abstract

Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps(SPMs) and as an absolute value using conventional region of interest(ROI) settings. Twenty-eight subjects, including 14 patients with mild AD (mean age: 66.4 +/- 12.1 years) and 14 normal controls (65.9 +/- 7.3 years) were studied. Regional cerebral blood flow (CBF) was measured with (H2O)-O-15 and positron emission tomography (PET). In the SPM analysis, the left posterior cingulate and left parietotemporal CBFs were significantly decreased in the patients with mild AD (P < 0.001). At a lower statistical threshold (P < 0.05), the right posterior cingulate and right parietotemporal CBFs were also significantly decreased in the AD patients. In the ROI studies, the left parietal and posterior cingulate CBFs in the patients with mild AD were significantly lowerthan those of the normal controls by analysis of variance and post-hoc Scheffe's test (P < 0.001). We conclude that posterior cingulate perfusion is decreased in mild AD, reflecting the pathological changes and metabolic reduction in the posterior cingulate gyrus that have previously been reported to occur in mild AD.

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Documento generato il 04/12/20 alle ore 03:51:15