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Titolo:
A method of reducing the opioid withdrawal intensity using progressively increasing doses of naloxone
Autore:
Langerman, L; Steingart, RA; Margolis, A; Yanai, J;
Indirizzi:
Hadassah Univ Hosp, Dept Anat & Cell Embryol, Ross Lab, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 3, volume: 42, anno: 1999,
pagine: 115 - 119
SICI:
1056-8719(199911)42:3<115:AMORTO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MORPHINE-DEPENDENT MICE; OPIATE WITHDRAWAL; DETOXIFICATION TREATMENT; PRECIPITATED WITHDRAWAL; PHYSICAL-DEPENDENCE; HEROIN-ADDICTS; NALTREXONE; ANTAGONISTS; MECHANISMS; TOLERANCE;
Keywords:
opioids; morphine; addiction; withdrawal; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Langerman, L Hadassah Univ Hosp, Dept Anat & Cell Embryol, Ross Lab, POB 12272, IL-91120 Jerusalem, Israel Hadassah Univ Hosp POB 12272 Jerusalem Israel IL-91120 srael
Citazione:
L. Langerman et al., "A method of reducing the opioid withdrawal intensity using progressively increasing doses of naloxone", J PHARM TOX, 42(3), 1999, pp. 115-119

Abstract

We assessed the withdrawal intensity in acutely morphine-dependent mice using a pretreatment with escalating doses of naloxone. All animals received a single dose of morphine (100 mg/kg) for the induction of acute opioid dependency. Group 1 (control) received three injections of normal saline and then naloxone 0.8 mg/kg. Group 2 received increasing pretreatment doses of naloxone (0.1, 0.2, and 0.4 mg/kg) and a challenge dose of 0.8 mg/kg. Group 3 received three injections of naloxone 0.1 mg/kg and a challenge dose of 0.8 mg/kg. Groups 3 and 5 were used to verify whether ED50 found in previousstudies was comparable with values obtained in the current experiments. The withdrawal intensity was determined by the number of jumps. The mice of group 1 exhibited significantly more jumps after 0.8 mg/kg of naloxone as compared with group 2. The number of jumps in response to naloxone between groups 1 and 2 and groups 2 and 3 was not significantly different. The results show that pretreatment with increasing naloxone doses significantly reduced the withdrawal intensity as compared with the control group; whereas pretreatment with repeated low antagonist did not reduce it significantly. (C)2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:43:03