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Titolo:
Etiology and age incidence of precocious puberty in girls: A multicentric study
Autore:
Cisternino, M; Arrigo, T; Pasquino, AM; Tinelli, C; Antoniazzi, F; Beduschi, L; Bindi, G; Borrelli, P; De Sanctis, V; Farello, G; Galluzzi, F; Gargantini, L; Lo Presti, D; Sposito, M; Tato, L;
Indirizzi:
Univ Pavia, Policlin San Matteo, IRCCS, Clin Pediat,Dept Pediat, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Pediat,Dept Pediat, I-27100 Pavia, Italy Univ Messina, Policlin Univ, I-98100 Messina, Italy Univ Messina MessinaItaly I-98100 Policlin Univ, I-98100 Messina, Italy Univ La Sapienza, Policlin Umberto I, Rome, Italy Univ La Sapienza Rome Italy a Sapienza, Policlin Umberto I, Rome, Italy Univ Verona, Policlin Borgo Roma, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 iclin Borgo Roma, I-37100 Verona, Italy Univ Florence, Hosp A Meyer, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 sp A Meyer, I-50121 Florence, Italy Arcispedale S Anna, Ferrara, Italy Arcispedale S Anna Ferrara ItalyArcispedale S Anna, Ferrara, Italy Univ Aquila, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100Univ Aquila, I-67100 Laquila, Italy Univ Catania, I-95124 Catania, Italy Univ Catania Catania Italy I-95124Univ Catania, I-95124 Catania, Italy Univ Perugia, Policlin Monteluce, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 lin Monteluce, I-06100 Perugia, Italy Pediat Hosp Bambin Gesu, Rome, Italy Pediat Hosp Bambin Gesu Rome ItalyPediat Hosp Bambin Gesu, Rome, Italy Hosp Treviglio, Pediat Sect, Treviglio, Italy Hosp Treviglio Treviglio Italy Treviglio, Pediat Sect, Treviglio, Italy Policlin San Matteo, IRCCS, Biometr Unit, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 ometr Unit, I-27100 Pavia, Italy
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
, volume: 13, anno: 2000, supplemento:, 1
pagine: 695 - 701
SICI:
0334-018X(200007)13:<695:EAAIOP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAUTERINE GROWTH-RETARDATION; MAGNETIC-RESONANCE; SEXUAL PRECOCITY;
Keywords:
central precocious puberty; girls; neurogenic abnormalities;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Cisternino, M Univ Pavia, Policlin San Matteo, IRCCS, Clin Pediat,Dept Pediat, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 ediat, I-27100 Pavia, Italy
Citazione:
M. Cisternino et al., "Etiology and age incidence of precocious puberty in girls: A multicentric study", J PED END M, 13, 2000, pp. 695-701

Abstract

We review the etiology and age incidence of precocious puberty in 438 girls examined between 1988-1998; 428 (97.7%) had central precocious puberty (CPP), the remaining 10 (2.3%) gonadotropin-independent precocious puberty (GIPP) of ovarian origin. The majority of CPP girls (59.6%) were aged between7-7.9 yr, 22.4% were 6 year olds, and only 18% were under 6 years old. Cranial CT and/or MRT performed in 304/428 girls, showed neurogenic abnormalities in 56/304 (18.4%) CPP girls; 30 (9.9%) were due to previously diagnosedintracranial abnormalities and the remaining 26 (8.5%) were detected at the diagnosis of CPP, The frequency of neurogenic CPP tended to be higher in girls under 4 years of age while the frequency of idiopathic CPP tended to be higher in girls aged between 7-7.9 years, but no statistically significant differences were found. Interestingly, some CNS anomalies either of tumoral or congenital origin were detected at presentation in 7% of the girls aged over 7 years, Other related or coincidental clinical anomalies, mainly due to genetic diseases, were observed in 22/304 (7.2%) patients, History of precocious maternal menarche was found in 12/304 (4%) girls. In conclusion, idiopathic CPP was observed in 74% of the girls in this study. Neurogenic anomalies or other coincidental or related clinical findings were observed in the remaining 26%, The increased frequency of idiopathic CPP in girls aged over 7 years may suggest an early, but otherwise normal onset of puberty in many of these girls as a consequence of the trend towards earlier maturation. Nonetheless, the finding of CNS anomalies also in the older patients, raises the question of whether these patients should undergo a completediagnostic work-up.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:32:18