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Titolo:
Endothelin-1-mediated retinal artery vasospasm and the rabbit electroretinogram
Autore:
Ciulla, TA; Pawlyk, BS; Harris, A; Oberoi, A; Miller, JW; Sandberg, MA;
Indirizzi:
Indiana Univ, Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA IndianaUniv Indianapolis IN USA 46202 halmol, Indianapolis, IN 46202 USA
Titolo Testata:
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
fascicolo: 4, volume: 16, anno: 2000,
pagine: 393 - 398
SICI:
1080-7683(200008)16:4<393:ERAVAT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, A Indiana Univ, Sch Med, Dept Ophthalmol, 702 Rotary Circle, Indianapolis, IN 46202 USA Indiana Univ 702 Rotary Circle Indianapolis IN USA 46202 202 USA
Citazione:
T.A. Ciulla et al., "Endothelin-1-mediated retinal artery vasospasm and the rabbit electroretinogram", J OCUL PH T, 16(4), 2000, pp. 393-398

Abstract

Electroretinogram (ERG) changes invariably accompany the selective interruption of the retinal circulation that occurs in human central retinal artery occlusion. Since arteriolar ligation or ocular hypertension in the rabbiteye is occasionally used to model human central retinal artery occlusion, we conducted the present study to determine whether selective interruption of the retinal circulation of the rabbit eye alters retinal function as measured by the ERG,The vasoconstrictor, endothelin-l, was injected into the vitreous of rabbits' eyes to induce complete vasospasm and selective interruption of the retinal circulation. This procedure was compared to vascular ligation of the ophthalmic and ciliary arteries in which both the retinal and choroidal circulations were interrupted. A total of 8 rabbits was studied. Circulation was monitored angiographically in half of the eyes, and retinal function was monitored by the ERG in the remaining eyes. Endothelin-1 obliterated retinal arteriolar blood flow without affecting choroidal blood now for at least 1 hr. Although ERG a-wave amplitude showed a small decline over 2 hr, b-wave and oscillatory potential amplitudes (measures of inner retinal function) showed no loss over this period. In contrast, ligation of the ophthalmic and ciliary arteries produced complete obliteration of both retinal arteriolar and choroidal blood flow and complete loss of the ERG after 2 min. Endothelin-1 induces acute, selective interruption of retinal arteriolar blood flow which has no significant physiologic effect on inner retinal function of the rabbit as monitored by the ERG. The avascular rabbit retina appears to be a poor choice for modeling human retinal artery occlusion.

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Documento generato il 24/09/20 alle ore 01:11:18