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Titolo:
Lesions of the amygdala central nucleus alter performance on a selective attention task
Autore:
Holland, PC; Han, JS; Gallagher, M;
Indirizzi:
Duke Univ, Dept Psychol, Durham, NC 27708 USA Duke Univ Durham NC USA 27708 ke Univ, Dept Psychol, Durham, NC 27708 USA Johns Hopkins Univ, Dept Psychol, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 sychol, Baltimore, MD 21218 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 20, anno: 2000,
pagine: 6701 - 6706
SICI:
0270-6474(20000901)20:17<6701:LOTACN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR PARIETAL CORTEX; BASAL FOREBRAIN LESIONS; REACTION-TIME-TASK; CHOLINERGIC SYSTEMS; COGNITIVE FUNCTIONS; DISRUPT INCREMENTS; RAT; DECREMENTS; INFUSIONS; NEURONS;
Keywords:
amygdala; central nucleus; selective attention; basal forebrain cholinergic system; reaction time; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Holland, PC Duke Univ, Dept Expt Psychol, Box 90086, Durham, NC 27708 USA Duke Univ Box 90086 Durham NC USA 27708 , Durham, NC 27708 USA
Citazione:
P.C. Holland et al., "Lesions of the amygdala central nucleus alter performance on a selective attention task", J NEUROSC, 20(17), 2000, pp. 6701-6706

Abstract

Previous studies showed a role for the amygdala central nucleus (CN) in attentional processing during the acquisition of Pavlovian associations. Boththe acquisition of conditioned orienting responses and the surprise-induced enhancement in the ability of conditioned stimuli to enter into new associations depend on the integrity of CN. In this experiment, the role of CN in the performance of a well-learned selective attention task was examined. Rats with ibotenic acid lesions of CN and control rats first learned a discrete-trial, multiple-choice reaction time task. On each trial, after a constant-duration ready signal, the rats were required to poke their noses intoone of three ports, guided by the brief illumination of one of those ports. Rats with CN lesions were slower to acquire the task than control rats but showed equivalent asymptotic sustained performance. Subsequent attentional challenges, which included reducing the duration of the port illuminationand varying the duration of the ready signal, had greater impact on the performance of lesioned than control rats. These data resemble those reportedfrom similar tasks after damage to the basal forebrain (BF) system. Together with earlier findings, these data support a role for CN in modulating visuospatial attention in action as well as in the acquisition of associations, perhaps by way of its projections to BF cholinergic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:28:17