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Titolo:
Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor
Autore:
Satoh, T; Furuta, K; Tomokiyo, K; Nakatsuka, D; Tanikawa, M; Nakanishi, M; Miura, M; Tanaka, S; Koike, T; Hatanaka, H; Ikuta, K; Suzuki, M; Watanabe, Y;
Indirizzi:
Osaka Biosci Inst, Dept Neurosci, Suita, Osaka 5650874, Japan Osaka BiosciInst Suita Osaka Japan 5650874 , Suita, Osaka 5650874, Japan Osaka Univ, Inst Microbial Dis, Div Immunol, Osaka, Japan Osaka Univ Osaka Japan v, Inst Microbial Dis, Div Immunol, Osaka, Japan Osaka Univ, Inst Prot Res, Div Prot Biosynth, Osaka, Japan Osaka Univ Osaka Japan , Inst Prot Res, Div Prot Biosynth, Osaka, Japan Osaka City Univ Med Sci, Dept Physiol, Osaka, Japan Osaka City Univ Med Sci Osaka Japan Med Sci, Dept Physiol, Osaka, Japan Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 50111, Japan Gifu Univ Gifu Japan 50111 Fac Engn, Dept Biomol Sci, Gifu 50111, Japan Nagoya City Univ, Sch Med, Dept Biochem, Nagoya, Aichi 467, Japan Nagoya City Univ Nagoya Aichi Japan 467 Biochem, Nagoya, Aichi 467, Japan Hokkaido Univ, Grad Sch Sci, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan d Sch Sci, Sapporo, Hokkaido, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 75, anno: 2000,
pagine: 1092 - 1102
SICI:
0022-3042(200009)75:3<1092:FRONCD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNFOLDED-PROTEIN RESPONSE; BIP MESSENGER-RNA; PC12 CELLS; ENDOPLASMIC-RETICULUM; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; CARCINOMA CELLS; GENE-EXPRESSION; INDUCTION;
Keywords:
Delta(7)-prostaglandin A(1); immunoglobulin heavy chain binding protein/glucose-regulated protein 78; neurite outgrowth; nerve growth factor; PC12 cells; dorsal root ganglion explants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, T Osaka Biosci Inst, Dept Neurosci, 6-2-4 Furuedai, Suita, Osaka 5650874, Japan Osaka Biosci Inst 6-2-4 Furuedai Suita Osaka Japan 5650874 Japan
Citazione:
T. Satoh et al., "Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor", J NEUROCHEM, 75(3), 2000, pp. 1092-1102

Abstract

Cyclopentenone prostaglandins (PGs) are known to arrest the cell cycle at the G(1) phase in vitro and to suppress tumor growth in vivo. However, their effects on neurons are unclear. Here, we report that some cyclopentenone PGs function as neurite outgrowth-promoting factors. They promoted neurite outgrowth from PC12 cells and from dorsal root ganglion explants but only in the presence of nerve growth factor (NGF), We refer to these PGs as neurite outgrowth-promoting PGs (NEPPs), Through study of the structure-functionrelationship of NEPP1-10 and related compounds, we found that the cross-conjugated dienone moiety of NEPPs was essential for promoting neurite outgrowth, and NEPP10 was concluded to be the best candidate for drug development. We also investigated the intracellular mechanism of the promotion by NEPPs and obtained evidence that immunoglobulin heavy chain binding protein/glucose-regulated protein 78 (BiP/GRP78) plays a role in the promotion, based on the following observations: Antisense nucleotides for BiP/GRP78 gene blocked the promotion of neurite outgrowth; BiP/GRP78 protein level increased in response to NEPPs; and overexpression of BiP/GRP78 protein by adenoviralgene transfer promoted the neurite outgrowth by NGF.

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Documento generato il 27/01/20 alle ore 01:22:59