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Titolo:
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5
Autore:
Iijima, K; Ando, K; Takeda, S; Satoh, Y; Seki, T; Itohara, S; Greengard, P; Kirino, Y; Nairn, AC; Suzuki, T;
Indirizzi:
Univ Tokyo, Sch Pharmaceut Sci, Lab Neurobiophys, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 obiophys, Bunkyo Ku, Tokyo 1130033, Japan Biooriented Technol Res Advancement Inst, Tokyo, Japan Biooriented TechnolRes Advancement Inst Tokyo Japan Inst, Tokyo, Japan Juntendo Univ, Sch Med, Dept Anat, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 Univ, Sch Med, Dept Anat, Tokyo 113, Japan Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 urosci Lab, New York, NY 10021 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 75, anno: 2000,
pagine: 1085 - 1091
SICI:
0022-3042(200009)75:3<1085:NPOABP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECTODOMAIN PHOSPHORYLATION; CYTOPLASMIC DOMAIN; CELLS; BRAIN; CDK5; IDENTIFICATION; COMPARTMENTS; EXPRESSION; METABOLISM; ACTIVATOR;
Keywords:
Alzheimer's beta-amyloid precursor protein; Alzheimer's disease; cyclin-dependent kinase 5; protein phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Univ Tokyo, Sch Pharmaceut Sci, Lab Neurobiophys, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
K. Iijima et al., "Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5", J NEUROCHEM, 75(3), 2000, pp. 1085-1091

Abstract

The mature form of Alzheimer's P-amyloid precursor protein (APP) is phosphorylated specifically at Thr(668) in neurons. In mature neurons, phosphorylated APP is detected in neurites, with dephosphorylated APP being found mostly in the cell body. In vitro, active cyclin-dependent kinase 5 (Cdk5) phosphorylated the cytoplasmic domain of APP at Thr(668). Treatment of mature neurons with an antisense oligonucleotide to Cdk5 suppressed Cdk5 expression and significantly diminished the level of phosphorylated APP, The expression of APP was unaffected in antisense-treated neurons. These results indicate that in neurons APP is phosphorylated by Cdk5, and that this may play arole in its localization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:26:16