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Titolo:
Oncostatin M-mediated growth inhibition of human glioblastoma cells does not depend on Stat3 or on mitogen-activated protein kinase activation
Autore:
Halfter, H; Stogbauer, F; Friedrich, M; Serve, S; Serve, H; Ringelstein, EB;
Indirizzi:
Univ Munster, Dept Neurol, D-48129 Munster, Germany Univ Munster MunsterGermany D-48129 pt Neurol, D-48129 Munster, Germany Univ Munster, Dept Internal Med Oncol A, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 d Oncol A, D-48129 Munster, Germany
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 75, anno: 2000,
pagine: 973 - 981
SICI:
0022-3042(200009)75:3<973:OMGIOH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY NEUROTROPHIC FACTOR; BREAST-CANCER CELLS; IN-VITRO; ASTROCYTE DIFFERENTIATION; LEUKEMIA-CELLS; M OSM; INTERLEUKIN-6; EXPRESSION; RECEPTOR; FIBROBLASTS;
Keywords:
cytokines; glioblastoma; oncostatin M; differentiation; Stat3; mitogen; activated protein kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Halfter, H Univ Munster, Dept Neurol, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
H. Halfter et al., "Oncostatin M-mediated growth inhibition of human glioblastoma cells does not depend on Stat3 or on mitogen-activated protein kinase activation", J NEUROCHEM, 75(3), 2000, pp. 973-981

Abstract

Oncostatin M (OSM) and other members of the interleukin-6 cytokines, like ciliary neurotrophic factor and leukemia inhibitory factor, can induce differentiation of glial cells. We have recently described that OSM inhibited the growth of human glioma cells in vitro and induced a cell morphology resembling that of mature astrocytes, Using the glioblastoma cell line 86HG39, we demonstrated that treatment of the glioma cells with OSM also leads to adifferentiation of the malignant glioma cells as judged by a strong increase in glial fibrillary acidic protein expression. The differentiation and the growth inhibition were not significantly blocked by expression of a dominant-negative (dn) signal transducer and activator of transcription (Stat)3protein. OSM exerted a reduction in DNA synthesis even in the presence of a high expression level of dnStat3. Moreover, inhibition of the ras-raf-mitogen-activated protein kinase (MAPK) pathway by the MAPK kinase 1 inhibitorPD98059 resulted in a synergistic enhancement of the OSM effect, indicating that the activation of this pathway counteracts the activity of the cytokine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 09:20:43