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Titolo:
Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons
Autore:
Yang, LY; Arnold, AP;
Indirizzi:
Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Brain Res Inst, Neuroendocrinol Lab, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 3, volume: 44, anno: 2000,
pagine: 308 - 319
SICI:
0022-3034(20000905)44:3<308:IOBATI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY NEUROTROPHIC FACTOR; RAT SPINAL NUCLEUS; ANDROGEN RECEPTOR IMMUNOREACTIVITY; DIMORPHIC MOTOR NUCLEUS; INSENSITIVE RATS; TARGET MUSCLES; NEURON SIZE; CORD; ESTROGEN; BULBOCAVERNOSUS;
Keywords:
BDNF; testosterone; androgen receptor; SNB motoneurons; soma size;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, LY Univ Calif Los Angeles, Dept Physiol Sci, 621 Charles E Young Dr S, Los Angeles, CA 90095 USA Univ Calif Los Angeles 621 Charles E Young Dr S Los Angeles CA USA 90095
Citazione:
L.Y. Yang e A.P. Arnold, "Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons", J NEUROBIOL, 44(3), 2000, pp. 308-319

Abstract

In androgen-sensitive motoneurons of the spinal nucleus of the bulbocavernosus (SNB), we investigated the interaction of BDNF (brain-derived neurotrophic factor) and testosterone to understand whether each factor gates the ability of the other to regulate androgen receptor expression and soma size,and whether each factor requires the presence of the other for its action. We axotomized SNB motoneurons and applied BDNF or PBS (phosphate-buffered saline) to the cut ends of the axons in rats that were castrated and treated with either testosterone or placebo. Control groups were either not castrated or not axotomized, or had intact SNB axons and were castrated and treated with testosterone or placebo. We found that testosterone determined theexpression of nuclear androgen receptor, and this effect was enhanced by both BDNF and contact with the target muscles. The effect of BDNF on androgen receptor expression was seen only when testosterone was present. In the regulation of soma size, BDNF dominated. The application of BDNF completely compensated for the loss of testosterone in castrated males so that the testosterone effect on soma size was seen only in intact SNB motoneurons and in axotomized motoneurons treated with PBS. Moreover, testosterone increasedandrogen receptor and soma size in axotomized SNB motoneurons, indicating that testosterone can act on sites other than the target muscles of the SNBto regulate each of these. These results indicate that the regulation of androgen receptor by testosterone does not require BDNF, but the regulation of androgen receptor by BDNF does require testosterone. The regulation of soma size by BDNF does not require high expression of nuclear androgen receptor. (C) 2000 John Wiley & Sons, Inc.

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Documento generato il 22/09/20 alle ore 19:06:05