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Titolo:
Antidopaminergic effects of 1,2,3,4-tetrahydroisoquinoline and salsolinol
Autore:
Antkiewicz-Michaluk, L; Michaluk, J; Romanska, I; Papla, I; Vetulani, J;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 8-9, volume: 107, anno: 2000,
pagine: 1009 - 1019
SICI:
0300-9564(2000)107:8-9<1009:AEO1AS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC NEUROTOXIN; BIOLOGICAL SAMPLES; PARKINSONS-DISEASE; HUMAN-BRAIN; ION; 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE; N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE; METABOLISM; OXIDATION;
Keywords:
salsolinol; 1,2,3,4-tetrahydroisoquinoline; apomorphine; haloperidol; dopamine metabolism; anti-dopaminergic activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Antkiewicz-Michaluk, L Polish Acad Sci, Inst Pharmacol, Smetna St 12, PL-31343 Krakow, Poland Polish Acad Sci Smetna St 12 Krakow Poland PL-31343
Citazione:
L. Antkiewicz-Michaluk et al., "Antidopaminergic effects of 1,2,3,4-tetrahydroisoquinoline and salsolinol", J NEURAL TR, 107(8-9), 2000, pp. 1009-1019

Abstract

Immediate behavioral and biochemical effects of single doses of 1,2,3,4-tetrahydroisoquinoline (TIQ, 50 mg/kg) and salsolinol (100 mg/kg), suspected of involvement in etiology of Parkinson's disease, were investigated. Apomorphine (0.25 mg/kg) or haloperidol (1 mg/kg) were administered to TIQ or salsolinol pretreated Wistar rats. In additional experiment the displacement of [H-3]apomorphine by TIQ, salsolinol and dopamine receptor agonists and antagonists was tested. Both tetrahydroisoquinolines only slightly affected behavior and dopamine metabolism in naive rats? but very effectively abolished the behavioral and biochemical effects of apomorphine (hyperactivity, depression of striatal HVA level). The behavioral and biochemical effects ofhaloperidol were unchanged by administration of TIQ nor salsolinol. The tetrahydroisoquinolines displaced [H-3]apomorphine from its binding sites with effectiveness comparable to that of dopamine. The results support the hypothesis that endogenous tetrahydroisoquinolines may play an important role in regulation of dopaminergic activity in non-senescent organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:31:12