Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ECT in Parkinson's disease - dopamine transporter visualised by [I-123]-beta-CIT SPECT
Autore:
Fall, PA; Ekberg, S; Granerus, AK; Granerus, G;
Indirizzi:
Linkoping Univ, Fac Hlth Sci, Dept Neurosci & Locomot, Div Geriatr, S-58183 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58183 riatr, S-58183 Linkoping, Sweden Linkoping Univ, Fac Hlth Sci, Dept Med & Care, Div Nucl Med, S-58183 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58183 l Med, S-58183 Linkoping, Sweden
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 8-9, volume: 107, anno: 2000,
pagine: 997 - 1008
SICI:
0300-9564(2000)107:8-9<997:EIPD-D>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-BRAIN-BARRIER; I-123 BETA-CIT; ELECTROCONVULSIVE-THERAPY; NEUROLOGICAL DISORDERS; IGG ANALYSES; BINDING; RAT; IODINE-123-BETA-CIT; PERMEABILITY; PRINCIPLES;
Keywords:
Parkinson's disease; electroconvulsive therapy; single photon emission computerized tomography (SPECT); [I-123]beta-CIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Fall, PA Linkoping Univ Hosp, Geriatr Sect, SE-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden SE-58185 Linkoping, Sweden
Citazione:
P.A. Fall et al., "ECT in Parkinson's disease - dopamine transporter visualised by [I-123]-beta-CIT SPECT", J NEURAL TR, 107(8-9), 2000, pp. 997-1008

Abstract

Parkinson's disease (PD) is characterised by a loss of dopaminergic neurones in the basal ganglia. These neurones may be visualised by single photon emission computed tomography (SPECT) with the cocaine analogue 2 beta-carboxymethyl-3-beta-(4-iodophenyl)tropane ([(123)]beta-CIT), which labels the dopamine reuptake sites in the nerve terminals. In order to evaluate the possibility to predict the outcome of ECT a prospective study was performed with six PD patients in whom the [I-123]beta-CIT uptake was measured before and after an electroconvulsive therapy (ECT) series. The side-to-side difference in the radiotracer uptake was found to be significantly lower in striatum located contralaterally to the part of the body with the most pronounced symptomathology. No significant change in uptake of the radioligand was seen after ECT. Patients with best uptake and thus with less advanced PD improved most after ECT. The possibility to use the [I-123]beta-CIT uptake to predict the outcome of ECT treatment has to be further evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:50:50