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Titolo:
Non-serotonergic potentiation by (-)-pindolol of DOI-induced forward locomotion in rats: possible involvement of beta-adrenoceptors?
Autore:
Kaur, P; Ahlenius, S;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ol, SE-17177 Stockholm, Sweden
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 8-9, volume: 107, anno: 2000,
pagine: 903 - 917
SICI:
0300-9564(2000)107:8-9<903:NPB(OD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONISTS NAD-299; SPONTANEOUS MOTOR-ACTIVITY; IN-VIVO; 5-HT1B RECEPTORS; EJACULATORY BEHAVIOR; EXTRACELLULAR 5-HT; FRONTAL-CORTEX; BRAIN; INHIBITION; 5-HYDROXYTRYPTAMINE;
Keywords:
serotonin receptors; beta-adrenoceptors; DOI; pindolol; locomotor activity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kaur, P Karolinska Inst, Dept Physiol & Pharmacol, Div Pharmacol, SE-17177Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 7177 Stockholm, Sweden
Citazione:
P. Kaur e S. Ahlenius, "Non-serotonergic potentiation by (-)-pindolol of DOI-induced forward locomotion in rats: possible involvement of beta-adrenoceptors?", J NEURAL TR, 107(8-9), 2000, pp. 903-917

Abstract

[1] We have previously shown that the beta-adrenergic/5-HT1 receptor partial agonist (-)-pindolol (2.0-32.0 mu molkg(-1)) enhances the increase in forward locomotion in rats produced by the 5-HT2 receptor agonist DOI (0.7 mumolkg(-1)) via net activation of post-synaptic 5-HT2 receptors. [2] It wasfound that neither the 5-HT1A receptor agonist and partial agonist, (+) 8-OH-DPAT (0.2-2.4 mu mol kg(-1)) and (S)-(-)-UH-301, respectively, nor the 5-HT1A receptor antagonist WAY-100635 (0.09-1.5 mu molkg(-1)), substituted for (-)pindolol in this in vivo behavioral model. [3] This also applies to the 5-HT1B receptor agonist and antagonist anpirtoline (0.3-4.0 mu mol kg(-1)) and isamoltane (1.0-64.0 mu mol kg(-1)), respectively. Neither of these compounds mimicked (-)-pindolol in its interactions with DOI. [4] The(-)-pindolol/DOI-induced increase in forward locomotion could be antagonized by the beta(1) adrenoceptor antagonist betaxolol (24 mu molkg(-1)). [5] It is suggested that the intrinsic efficacy of (-)-pindolol at beta-adrenoceptors is an important aspect of its in vivo pharmacodynamic profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:01:53