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Titolo:
Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage
Autore:
Kim, HM; Shin, HY; Jeong, HJ; An, HJ; Kim, NS; Chae, HJ; Kim, HR; Song, HJ; Kim, KY; Baek, SH; Cho, KH; Moon, BS; Lee, YM;
Indirizzi:
Wonkwang Univ, Coll Pharm, Oriental Med Res Ctr, Dept Oriental Pharm, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk SouthKorea 570749 Chonbuk, South Korea Wonkwang Univ, Sch Med, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk South Korea 570749 Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk South Korea 570749 Chonbuk, South Korea Wonkwang Univ, Coll Oriental Med, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk South Korea 570749 Chonbuk, South Korea Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk South Korea 570749 Chonbuk, South Korea
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 3, volume: 14, anno: 2000,
pagine: 191 - 196
SICI:
0895-8696(200006)14:3<191:RIBEII>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; INTERFERON-GAMMA PRODUCTION; SEVERE ATOPIC-DERMATITIS; T-CELLS; CEREBROSPINAL-FLUID; LYMPHOCYTE-T; INTERLEUKIN-4; INFECTION; SECRETION; INVITRO;
Keywords:
IFN-gamma; IL-2; IL-4; IL-6; IgE; cerebral infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, YM Wonkwang Univ, Coll Pharm, Oriental Med Res Ctr, Dept Oriental Pharm, Iksan City 570749, Chonbuk, South Korea Wonkwang Univ Iksan City Chonbuk South Korea 570749 , South Korea
Citazione:
H.M. Kim et al., "Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage", J MOL NEURO, 14(3), 2000, pp. 191-196

Abstract

Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-gamma, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients withcerebral infarction. However, serum IFN-gamma levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:17:54