Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Deacylation and reacylation of neural membrane glycerophospholipids - A matter of life and death
Autore:
Farooqui, AA; Horrocks, LA; Farooqui, T;
Indirizzi:
Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 lar Biochem, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 3, volume: 14, anno: 2000,
pagine: 123 - 135
SICI:
0895-8696(200006)14:3<123:DARONM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSOLIC PHOSPHOLIPASE A(2); RAT-BRAIN MICROSOMES; ACYL-COA SYNTHETASE; TUMOR-NECROSIS-FACTOR; ARACHIDONIC-ACID INCORPORATION; COENZYME-A SYNTHETASE; FATTY-ACIDS; DOCOSAHEXAENOIC ACID; BOVINE BRAIN; NEUROLOGICAL DISORDERS;
Keywords:
reacylation; deacylation; acyltransferase; phospholipase A(2); arachidonic acid; eicosanoids; lysophospholipids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Horrocks, LA Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Columbus, OH 43210 USA
Citazione:
A.A. Farooqui et al., "Deacylation and reacylation of neural membrane glycerophospholipids - A matter of life and death", J MOL NEURO, 14(3), 2000, pp. 123-135

Abstract

The deacylation-reacylation cycle is an important mechanism responsible for the introduction of polyunsaturated fatty acids into neural membrane glycerophospholipids. It involves four enzymes, namely acyl-CoA synthetase, acyl-CoA hydrolase, acyl-CoA: lysophospholipid acyltransferase, and phospholipase A,. All of these enzymes have been purified and characterized from brain tissue. Under normal conditions, the stimulation of neural membrane receptors by neurotransmitters and growth factors results in the release of arachidonic acid from neural membrane glycerophospholipids. The released arachidonic acid acts as a second messenger itself. It can be further metabolizedto eicosanoids, a group of second messengers involved in a variety of neurochemical functions. A lysophospholipid, the second product of reactions catalyzed by phospholipase A,, is rapidly acylated with acyl-CoA, resulting in the maintenance of the normal and essential neural membrane glycerophospholipid composition. However, under pathological situations (ischemia), the overstimulation of phospholipase A, results in a rapid generation and accumulation of free fatty acids including arachidonic acid, eicosanoids, and lipid peroxides. This results in neural inflammation, oxidative stress, and neurodegeneration. In neural membranes, the deacylation-reacylation cycle maintains a balance between free and esterified fatty acids, resulting in lowlevels of arachidonic acid and lysophospholipids. This is necessary for not only normal membrane integrity and function, but also for the optimal activity of the membrane-bound enzymes, receptors, and ion channels involved in normal signal-transduction processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:01:16