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Titolo:
Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression
Autore:
Baker, PW; Rye, KA; Gamble, JR; Vadas, MA; Barter, PJ;
Indirizzi:
Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA, Australia UnivAdelaide Adelaide SA Australia p, Dept Med, Adelaide, SA, Australia Hanson Ctr Canc Res, Adelaide, SA, Australia Hanson Ctr Canc Res AdelaideSA Australia c Res, Adelaide, SA, Australia Royal Adelaide Hosp, Cardiovasc Invest Unit, Adelaide, SA 5000, Australia Royal Adelaide Hosp Adelaide SA Australia 5000 elaide, SA 5000, Australia
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 8, volume: 41, anno: 2000,
pagine: 1261 - 1267
SICI:
0022-2275(200008)41:8<1261:PCORHD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECITHIN-CHOLESTEROL ACYLTRANSFERASE; FATTY-ACID COMPOSITION; APOLIPOPROTEIN-A-I; PHOSPHATIDYLCHOLINE; HDL; ATHEROSCLEROSIS; PARAOXONASE; OXIDATION; COMPLEXES; BINDING;
Keywords:
vascular cell adhesion molecule 1; VCAM-1; human umbilical vein endothelial cells; HUVEC; TNF-alpha; IL-1; fatty acid composition; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, PW Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA, Australia Univ Adelaide Adelaide SA Australia d, Adelaide, SA, Australia
Citazione:
P.W. Baker et al., "Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression", J LIPID RES, 41(8), 2000, pp. 1261-1267

Abstract

The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (](HUVECs) was investigated. PC speciescon taining palmitoyl- in the sn-1 position and palmitoyl- (DPPC), arachidonyl- (PAPC), linoleoyl- (PLPC) or oleoyl- (POPC) in the sn-2 position werecompared. These PC species were studied as components of reconstituted high density lipoproteins (rHDL) (containing apolipoprotein A-I [apoA-I] as the sole protein) or as small unilamellar vesicles (SUVs), The rHDL containing PLPC and PAPC inhibited VCAM-1 expression in activated HUVECs by 95 and 70%, respectively, at an apoA-I concentration of 16 mu M. At this concentration of apoA-I, POPC rHDL inhibited by only 16% and DPPC rHDL did not inhibit at all. These differences could not be explained by differential binding of the rHDL to HUVECs. The same hierarchy of inhibitory activity was observed when these PC species were presented to the cells as SUVs but only when the SUVs also contained an;antioxidant.jlr It was concluded that rHDL PC isresponsible for their inhibitory activity and that this varies widely withdifferent PC species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:14:41