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Titolo:
ANGIOTENSIN-II-INDUCED PHOSPHOINOSITIDE PRODUCTION AND ATRIAL-NATRIURETIC-PEPTIDE RELEASE IN RAT ATRIAL TISSUE
Autore:
SOUALMIA H; BARTHELEMY C; MASSON F; MAISTRE G; EURIN J; CARAYON A;
Indirizzi:
CHU PITIE SALPETRIERE,SERV BIOCHIM MED,91 BLVD HOP F-75634 PARIS 13 FRANCE
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 29, anno: 1997,
pagine: 605 - 611
SICI:
0160-2446(1997)29:5<605:APPAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CYTOSOLIC-FREE CALCIUM; PHOSPHATIDYLINOSITOL PATHWAY; NITRIC-OXIDE; SECRETION; MYOCYTES; STIMULATION; HEART; CARDIOMYOCYTES; MODULATION;
Keywords:
ANGIOTENSIN II; INOSITOL PHOSPHATES; ATRIAL NATRIURETIC PEPTIDE; LOSARTAN; CA2+;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
H. Soualmia et al., "ANGIOTENSIN-II-INDUCED PHOSPHOINOSITIDE PRODUCTION AND ATRIAL-NATRIURETIC-PEPTIDE RELEASE IN RAT ATRIAL TISSUE", Journal of cardiovascular pharmacology, 29(5), 1997, pp. 605-611

Abstract

The effect of angiotensin II (Ang II) on inositol phosphate (IP) production and atrial natriuretic peptide (ANP) release was studied in sliced rat atrial tissue. The ability of Ang II (10(-7) M) to stimulate IP accumulation was detected after 1 min of incubation, and the maximalincrease was observed at 5 min. In (2-H-3) inositol-labeled atrial tissue, Ang II induced the formation of (2-H-3) inositol monophosphate (IP1) in a dose-dependent manner. The effect of Ang II (10(-7) M) on IP1 was prevented by losartan (10(-7) M) but was not affected by PD123319 (10(-7) M). Similar effects were observed on Ang II-induced ANP release in the presence of these antagonists. The mechanism of ANP liberation induced by this peptide was independent of cyclic adenosine monophosphate (cAMP) and regulated by nitric oxide (NO). The role of Ca2+ inthe effect of Ang II was tested by 1,2-bis (o-aminophenoxy)-ethane-N,N,N ',N '- tetraacetic acid tetra (acetoxymethyl) ester (BAPTA-AM; 10(-5) M), a chelator of intracellular Ca2+ that prevented the release ofANP by Ang LI stimulation We concluded that Ang II induced IP production and ANP release through AT(1) receptors. Stimulation of ANP release by Ang II was dependent on intracellular Ca2+.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:25:20