Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF TILISOLOL, A NONSELECTIVE BETA-ADRENERGIC BLOCKER, ON THE MEMBRANE CURRENTS OF ISOLATED GUINEA-PIG VENTRICULAR MYOCYTES
Autore:
TAKAGI S; KIHARA Y; MITSUIYE T; WANG ZR; SASAYAMA S;
Indirizzi:
KYOTO UNIV HOSP,GRAD SCH MED,DEPT CARDIOVASC MED INTERNAL MED III,54 SHOGOIN KAWAHARACHO KYOTO 606 JAPAN KYOTO UNIV HOSP,GRAD SCH MED,DEPT CARDIOVASC MED INTERNAL MED III KYOTO 606 JAPAN KYOTO UNIV HOSP,GRAD SCH MED,DEPT PHYSIOL KYOTO 606 JAPAN
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 29, anno: 1997,
pagine: 593 - 598
SICI:
0160-2446(1997)29:5<593:EOTANB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT K+ CHANNELS; CARDIAC MYOCYTES; POTASSIUM CHANNEL; ADENOSINE-TRIPHOSPHATE; CONTRACTILE FAILURE; HEART-CELLS; MUSCLE; MYOCARDIUM; ACTIVATION;
Keywords:
TILISOLOL; MYOCYTES; BETA-ADRENOCEPTOR; TRANSMEMBRANE CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Takagi et al., "EFFECTS OF TILISOLOL, A NONSELECTIVE BETA-ADRENERGIC BLOCKER, ON THE MEMBRANE CURRENTS OF ISOLATED GUINEA-PIG VENTRICULAR MYOCYTES", Journal of cardiovascular pharmacology, 29(5), 1997, pp. 593-598

Abstract

The effects of tilisolol, a nonselective beta-adrenoceptor blocker, on transmembrane ionic currents were studied in single guinea pig ventricular myocytes by using the whole-cell voltage clamp technique. In the absence of beta-adrenergic stimulation, 10 mu M tilisolol, a concentration higher than that used in the clinical therapeutic regimen, did not affect the L-type Ca2+ current (I-Ca), the inwardly rectifying K+ current (I-Kl), or the delayed rectifying K+ current (I-K). In addition, it did not induce currents through the adenosine triphosphate (ATP)-sensitive K+ channels. However, under the nonselective P-adrenergic stimulation with 1 mu M isoproterenol, 1 mu M tilisolol almost completely reversed the agonist-induced increase of I-K. The increase of I-Ca by isoproterenol was blocked only by similar to 30% with tilisolol. Weconcluded that, at therapeutic concentrations (0.01-0.15 mu M), tilisolol is a pure beta-adrenoceptor antagonist that has no direct effectson the transmembrane ionic currents of mammalian ventricular myocytes, such as I-Ca, I-Kl, or I-K. Comparison of the dose-dependent effectsof tilisolol on I-Ca and I-K suggested that tilisolol may selectivelyinhibit catecholamine-induced increase of I-K at the therapeutic concentrations. The virtually selective inhibition of I-K, leaving I-Ca intact, may be favorable to prevent the catecholamine-induced arrhythmiawithout inhibiting contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:41:34