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Titolo:
Cells in the posterior thalamus project to both amygdala and temporal cortex: A quantitative retrograde double-labeling study in the rat
Autore:
Doron, NN; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Labs Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 WM Keck Labs Neurobiol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 425, anno: 2000,
pagine: 257 - 274
SICI:
0021-9967(20000918)425:2<257:CITPTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL GENICULATE-BODY; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; AUDITORY THALAMOCORTICAL SYSTEM; FEAR-POTENTIATED STARTLE; SUPERIOR COLLICULUS; HORSERADISH-PEROXIDASE; PERIRHINAL CORTEX; AFFERENT CONNECTIONS; INFERIOR COLLICULUS; LATERAL AMYGDALA;
Keywords:
medial geniculate nucleus; lateral posterior nucleus; posterior intralaminar nucleus; auditory cortex; perirhinal cortex; fear conditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: LeDoux, JE NYU, Ctr Neural Sci, WM Keck Labs Neurobiol, 4 Washington Pl,Room 809, NewYork, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
N.N. Doron e J.E. LeDoux, "Cells in the posterior thalamus project to both amygdala and temporal cortex: A quantitative retrograde double-labeling study in the rat", J COMP NEUR, 425(2), 2000, pp. 257-274

Abstract

Auditory information from the posterior thalamus reaches the lateral nucleus of the amygdala (LA) by way of two pathways: a direct thalamo-amygdala projection and a polysynaptic thalamo-cortico-amygdala projection. However, the quantitative extent of thalamic neurons that project to the LA or to the auditory association cortex (AAC) is not known. Furthermore, the extent and topographical distribution of bifurcating cells that project to both LA and AAC are also unknown. Therefore, separate tracers were injected into LAand either into all of AAC or within discrete regions of AAC, such as temporal areas TE3 or perirhinal cortex (PRh), and quantitative analyses were performed on labeling within the subregions of the auditory thalamus in rats. Following LA injections, retrogradely labeled cells were most numerous inthe posterior intralaminar nucleus (PIN; 48.0% of all labeled thalamic cells), whereas labeled cells following injections of the entire AAC were mostnumerous in the dorsal division of the medial geniculate nucleus (MGd; 32.9% of all labeled thalamic cells). Following AAC injections localized to only TE3, the MGd again had the majority of labeled cells (35.9%), whereas following AAC injections localized to PRh, the PIN had the most labeled cells(32.8%). Double-labeled cells were found in all the thalamic regions studied and were most commonly observed in the PIN (43.7% of all double-labeled cells following injections into LA and throughout the AAC). The percentage of double-labeled cells as a proportion of either LA-projecting or AAC-projecting cells varied among the thalamic nuclei studied, ranging from 2.9% upto 42.4%. The topographic distribution of double-labeled cells in the thalamic nuclei resembled that of single-labeled cells following LA injections more than single-labeled cells following AAC injection. These findings suggest that double-labeled cells contribute substantially to many of the direct thalamo-amygdala and indirect thalamo-AAC-amygdala projections. Among other functions, these bifurcating cells may help regulate the processing of input to the LA arriving from these two pathways to allow for certain types of plasticity in the LA during fear conditioning. J. Comp. Neurol. 425: 257-274, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 14/07/20 alle ore 05:35:59