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Titolo:
Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice
Autore:
Schatteman, GC; Hanlon, HD; Jiao, CH; Dodds, SG; Christy, BA;
Indirizzi:
Univ Iowa, Iowa City, IA 52245 USA Univ Iowa Iowa City IA USA 52245Univ Iowa, Iowa City, IA 52245 USA Univ Texas, Hlth Sci Ctr, San Antonio, TX USA Univ Texas San Antonio TX USA v Texas, Hlth Sci Ctr, San Antonio, TX USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 4, volume: 106, anno: 2000,
pagine: 571 - 578
SICI:
0021-9738(200008)106:4<571:BAABRI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW; ANGIOGENESIS; NEOVASCULARIZATION; EXPRESSION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Schatteman, GC Univ Iowa, BSB 1-402, Iowa City, IA 52245 USA Univ Iowa BSB1-402 Iowa City IA USA 52245 ty, IA 52245 USA
Citazione:
G.C. Schatteman et al., "Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice", J CLIN INV, 106(4), 2000, pp. 571-578

Abstract

Endothelial cell progenitors, angioblasts, have been detected in the peripheral blood of adult humans, mice, and rabbits. These cells have been shownto incorporate into the endothelium of newly forming blood vessels in pathological and nonpathological conditions. Here we investigated the possibility that the CD34-expressing leukocytes (CD34(+) cells) that appear to be enriched for angioblasts could be used to accelerate the rate of blood-flow restoration in nondiabetic and diabetic mice undergoing neovascularization due to hindlimb ischemia. CD34(+) cells did not accelerate the restoration of flow in nondiabetic mice, but dramatically increased it in diabetic mice. Furthermore, CD34(+) cells derived from type 1 diabetics produced fewer differentiated endothelial cells in culture than did their type 2 diabetic- or nondiabetic-derived counterparts. In vitro experiments suggest that hyperglycemia per se does not alter the ability of angioblasts to differentiate or of angioblast-derived endothelial cells to proliferate. In contrast, hyperinsulinemia may enhance angioblast differentiation but impair angioblast-derived endothelial cell survival or proliferation. Our findings suggest that CD34(+) cells may be a useful tool for therapeutic angiogenesis in diabetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:57:36