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Titolo:
Risk of myocardial infarction after oophorectomy and hysterectomy
Autore:
Falkeborn, M; Schairer, C; Naessen, T; Persson, I;
Indirizzi:
Univ Uppsala, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden Univ Uppsala Uppsala Sweden Hlth & Caring Sci Geriatr, Uppsala, Sweden NCI, Environm Epidemiol Branch, Rockville, MD USA NCI Rockville MD USANCI, Environm Epidemiol Branch, Rockville, MD USA Univ Uppsala Hosp, Dept Gynecol & Obstet, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden Dept Gynecol & Obstet, Uppsala, Sweden Karolinska Inst, Dept Med Epidemiol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Med Epidemiol, Stockholm, Sweden
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 8, volume: 53, anno: 2000,
pagine: 832 - 837
SICI:
0895-4356(200008)53:8<832:ROMIAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; PREMENOPAUSAL HYSTERECTOMY; CARDIOVASCULAR MORTALITY; REPRODUCTIVE FACTORS; UTERINE MYOMAS; WOMEN; MENOPAUSE; AGE; PROGESTOGEN; ESTROGEN;
Keywords:
hysterectomy; oophorectomy; acute myocardial infarction; case cohort study; natural menopause; myoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Falkeborn, M Dept Geriatr, POB 609, S-75125 Uppsala, Sweden Dept Geriatr POB 609 Uppsala Sweden S-75125 Uppsala, Sweden
Citazione:
M. Falkeborn et al., "Risk of myocardial infarction after oophorectomy and hysterectomy", J CLIN EPID, 53(8), 2000, pp. 832-837

Abstract

To determine the risk of developing a first myocardial infarction after a hysterectomy and/or oophorectomy. Case-cohort analysis performed among 17,126 women in the Uppsala Health Care Region of Sweden, who had undergone a hysterectomy and/or oophorectomy in 1965 to 1983. Record linkage was used for follow-up and medical records to ascertain the actual history of oophorectomy. Risk estimates were calculated by relating the observed number of cases in the cohort to that expected on the basis of incidence rates in the population. Overall, 214 cases of myocardial infarction were observed. In premenopausal women a bilateral oophorectomy alone tended to increase the relative risk 1.6; 95% CI 0.8-3.1, but this operation combined with hysterectomy increased the risk only among those aged 50 and over at surgery. Hysterectomy at premenopausal age or unilateral oophorectomy did not alter the riskof myocardial infarction. In naturally menopausal women, hysterectomy-mainly for uterine myoma-was associated with a four-fold increase in relative risk (3.8; 95% CI 1.9-7.8). Hysterectomy for treatment of myoma performed after a natural menopause is linked to an excess risk for myocardial infarction. Bilateral oophorectomy before menopause may increase the risk of myocardial infarction. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:54:10