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Titolo:
Rapid method for estimating the octanol-water partition coefficient (log P-ow) by microemulsion electrokinetic chromatography
Autore:
Poole, SK; Durham, D; Kibbey, C;
Indirizzi:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Dept Chem, Ann Arbor, MI 48105 USA Warner Lambert Parke Davis Ann Arbor MI USA 48105 Ann Arbor, MI 48105 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 745, anno: 2000,
pagine: 117 - 126
SICI:
1387-2273(20000804)745:1<117:RMFETO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ENERGY RELATIONSHIP ANALYSIS; THIN-LAYER CHROMATOGRAPHY; REVERSED-PHASE; STATIONARY PHASES; CAPACITY FACTORS; RP-HPLC; HYDROPHOBICITY; LIPOPHILICITY; SELECTIVITY;
Keywords:
octanol-water partition coefficient; microemulsion electrokinetic chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Poole, SK Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Dept Chem, 2800 Plymouth Rd, Ann Arbor, MI 48105 USA Warner Lambert Parke Davis 2800 Plymouth Rd Ann Arbor MI USA 48105
Citazione:
S.K. Poole et al., "Rapid method for estimating the octanol-water partition coefficient (log P-ow) by microemulsion electrokinetic chromatography", J CHROMAT B, 745(1), 2000, pp. 117-126

Abstract

Several surfactant systems were evaluated based on their system constants determined by the solvation parameter model for the design of a surrogate chromatographic model for the rapid estimation of octanol-water partition coefficient (log P-ow) by microemulsion electrokinetic chromatography. The system constant ratios responsible for the log P-ow partition system are (nearly) the same as those for the microemulsion system containing sodium dodecyl sulfate (1.4% w/v), butan-1-ol (8% v/v) and heptane (1.2% v/v). Neutral and basic compounds are analyzed using a fused-silica capillary column witha 50 mM sodium phosphate-sodium berate (3:2) buffer at pH 10. Weakly acid compounds require the use of sulfonated silica capillary column and a 50 mMsodium phosphate buffer at pH 3. For 29 varied neutral and weakly basic compounds the average error between log P-ow estimated using MEEKC and literature values was +/-0.12 over a log P-ow range from 0.3 to 5.8. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:43