Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Gender and seasonally related differences in myocardial recovery and susceptibility to sotalol-induced arrhythmias in isolated rabbit hearts
Autore:
Spear, JF; Moore, EN;
Indirizzi:
Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Anim Biol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 8, volume: 11, anno: 2000,
pagine: 880 - 887
SICI:
1045-3873(200008)11:8<880:GASRDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; VENTRICULAR MYOCYTES; REPOLARIZATION; MECHANISMS; CURRENTS; CHANNEL; DRUGS; DEATH;
Keywords:
triggered activity; myocardial refractoriness; long QT interval; delayed rectifier potassium channel;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Spear, JF Univ Penn, Sch Vet Med, Dept Anim Biol, 3800 Spruce St,Suite 201E, Philadelphia, PA 19104 USA Univ Penn 3800 Spruce St,Suite 201E Philadelphia PA USA 19104 SA
Citazione:
J.F. Spear e E.N. Moore, "Gender and seasonally related differences in myocardial recovery and susceptibility to sotalol-induced arrhythmias in isolated rabbit hearts", J CARD ELEC, 11(8), 2000, pp. 880-887

Abstract

Introduction: Gender differences and seasonal variations in cardiac electrophysiology and susceptibility to arrhythmias have been described clinically. The present study was undertaken to determine if there are similar gender and seasonally related differences in the electrophysiology of the rabbitheart. Methods and Results: We analyzed epicardial electrograms, left ventricularendocardial monophasic action potentials (MAPs), and simulated X and Y lead ECGs from 145 isolated rabbit hearts studied over a period of 41 months. Hearts from males had seasonal increases in the duration of myocardial recovery, During the months of June to September compared with October to January and February to May, epicardial activation-recovery intervals (231.6 +/-23.4 vs 215.6 +/- 19.2 and 213.5 +/- 18.8 msec, P = 0.003), MAP durations (256.5 +/- 25.4 vs 237.0 +/- 19.6 and 230.7 +/- 26.4 msec, P < 0.001), and QT intervals (278.3 +/- 25.6 vs 267.3 +/- 11.8 and 261.3 +/- 13.0 msec, P =0.037) were longer. Overall; hearts from females had shorter QT intervals than males (257.7 +/- 15.7 vs 270.1 +/- 20.3 msec, P < 0.001), and this difference was reflected in their shorter epicardial activation-recovery intervals and MAP durations, However, hearts;from females showed a greater prolongation of epicardial recovery (P = 0.007) and greater incidence of arrhythmias (P < 0.001) with sotalol than males, Also, the incidence of arrhythmias was greater in the winter months October to May (P < 0.001). Conclusion: The isolated rabbit heart provides a spontaneous model of gender and seasonally related differences in cardiac electrophysiology and arrhythmia susceptibility. These differences may be related to variation in theexpression of or regulation of the membrane ion channels mediating repolarization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:27:46