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Titolo:
Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-spherewater molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI
Autore:
Aime, S; Gianolio, E; Terreno, E; Giovenzana, GB; Pagliarin, R; Sisti, M; Palmisano, G; Botta, M; Lowe, MP; Parker, D;
Indirizzi:
Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy Univ Turin TurinItaly I-10125 partimento Chim IFM, I-10125 Turin, Italy Univ Insubria, Dipartimento Chim Fis & Matemat, I-20133 Milan, Italy Univ Insubria Milan Italy I-20133 im Fis & Matemat, I-20133 Milan, Italy Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Med, I-28100 Novara, Italy Univ Piemonte Orientale Amedeo Avogadro Novara Italy I-28100 vara, Italy Univ Piemonte Orientale, Dipartimento Sci & Tecnol Avanzate, I-10131 Alesandria, Italy Univ Piemonte Orientale Alesandria Italy I-10131 10131 Alesandria, Italy Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Durham Durham England DH1 3LE m, Dept Chem, Durham DH1 3LE, England
Titolo Testata:
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
fascicolo: 4, volume: 5, anno: 2000,
pagine: 488 - 497
SICI:
0949-8257(200008)5:4<488:TGAEFT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXOMETRIC INVESTIGATIONS; GADOLINIUM(III) COMPLEXES; AMINO CARBOXYLATES; HYDRATION NUMBERS; PH-DEPENDENCE; NMR; RELAXIVITIES; GD; EXCHANGE; LUMINESCENCE;
Keywords:
gadolinium(III) complex; MRI contrast agent; luminescence; human serum albumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Aime, S Univ Turin, Dipartimento Chim IFM, Via Pietro Giuria 7, I-10125 Turin, Italy Univ Turin Via Pietro Giuria 7 Turin Italy I-10125 5 Turin, Italy
Citazione:
S. Aime et al., "Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-spherewater molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI", J BIOL I CH, 5(4), 2000, pp. 488-497

Abstract

Two novel gadolinium(III) chelates based on the structure of the heptadentate macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A) ligand have been synthesized and their relaxometric and luminescent properties thoroughly investigated. They contain two water molecules in the inner coordination sphere in fast exchange with the bulk solvent and bear either a p-bromobenzyl or a p-phosphonatomethylbenzanilido substituent for promoting further interaction with macromolecular substrates. Upon interaction with human serum albumin the expected relaxation enhancement is not observed owing to displacement of the two inner-sphere water molecules of the complexes by a donor atom (likely from a carboxylate group) on the protein and possibly the phosphate anion of the buffered solution, respectively. We modeled the observed behavior by measuring the decrease of the relaxation rate ofthe water protons upon addition of malonate anion to aqueous solutions of the complexes. Conversely, no change in the hydratation state of the Gd(III) center for both complexes has been observed when the substrate for the formation of the macromolecular adduct is represented by poly-beta-cyclodextrin.

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Documento generato il 29/09/20 alle ore 12:24:28