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Titolo:
Central histamine contributed to temperature-induced polypnea in mice
Autore:
Izumizaki, M; Iwase, M; Kimura, H; Kuriyama, T; Homma, I;
Indirizzi:
Showa Univ, Sch Med, Dept Physiol 2, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 iol 2, Shinagawa Ku, Tokyo 1428555, Japan Chiba Univ, Sch Med, Dept Chest Med, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Med, Dept Chest Med, Chiba 2608670, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 89, anno: 2000,
pagine: 770 - 776
SICI:
8750-7587(200008)89:2<770:CHCTTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-TEMPERATURE; ALPHA-FLUOROMETHYLHISTIDINE; BREATHING PATTERN; RAT-BRAIN; RESPONSES; INHIBITOR; NEURONS; HYPOXIA; FIBERS; NERVE;
Keywords:
breathing pattern; carbon dioxide; alpha-fluoromethylhistidine hydrochloride; respiration; plethysmograph;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Homma, I Showa Univ, Sch Med, Dept Physiol 2, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 yo 1428555, Japan
Citazione:
M. Izumizaki et al., "Central histamine contributed to temperature-induced polypnea in mice", J APP PHYSL, 89(2), 2000, pp. 770-776

Abstract

Breathing pattern is influenced by body temperature. However, the central mechanism for changing breathing patterns is unknown. Central histamine is involved in heat loss mechanisms in behavioral studies, but little is knownabout its effect on breathing patterns. We examined first the effect of body temperature on breathing patterns with increasing hypercapnia in conscious mice and then that of the depletion of central histamine by S(+)-alpha-fluoromethylhistidine hydrochloride (alpha-FMH) (100 mg/kg ip), a specific inhibitor of histidine decarboxylase, at normal and raised body temperatures. A raised body temperature increased respiratory frequency with reductionsin both inspiratory and expiratory time and decreased tidal volume. On theother hand, alpha-FMH lowered respiratory frequency with a prolongation ofexpiratory time at the raised temperature; however, this was not observed at a normal temperature. These results indicate that central histamine contributes to an increase in respiratory frequency as a result of a reduction in expiratory time when body temperature is raised.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:48:39