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Titolo:
A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats
Autore:
Chen, KJD; Alway, SE;
Indirizzi:
W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Div Exercise Physiol, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 Physiol, Morgantown, WV 26506 USA Univ S Florida, Dept Anat, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 Florida, Dept Anat, Tampa, FL 33612 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 89, anno: 2000,
pagine: 606 - 612
SICI:
8750-7587(200008)89:2<606:APLOCD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLEUS MUSCLE; HINDLIMB SUSPENSION; MESSENGER-RNAS; FIBER FUNCTION; AGED RATS; YOUNG; EXPRESSION; RECOVERY; MYOGENIN; MASS;
Keywords:
aging; disuse; beta-agonist; muscle strength; isometric contraction; hypokinesia; myosin heavy chain; sarcopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Alway, SE W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Div Exercise Physiol, POB 9227, Morgantown, WV 26506 USA W Virginia Univ POB 9227 Morgantown WV USA 26506 n, WV 26506 USA
Citazione:
K.J.D. Chen e S.E. Alway, "A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats", J APP PHYSL, 89(2), 2000, pp. 606-612

Abstract

Supraphysiological levels of clenbuterol (CL) reduce muscle degradation inboth young and old animals; however, these pharmacological levels induce side effects that are unacceptable in the elderly. In this study, we tested the hypothesis that a "physiological" dose of CL (10 mu g . kg(-1). day(-1)) would attenuate the loss of in situ isometric force and mass in muscles of senescent rats during hindlimb suspension (HS). Adult (3 mo) and senescent (38 mo) Fischer 344 x Brown Norway rats received CL or a placebo during 21 days of normal-weight-bearing or RS conditions (8 rats/age group). HS reduced soleus muscle weight-to-body weight ratio by 31%, muscle cross-sectional area by 37%, and maximal isometric tetanic force (P-o) by 76% in senescent rats. CL attenuated the loss of P-o and muscle weight by 17 and 8%, respectively, in the soleus of senescent rats relative to HS+placebo conditions, but it did not improve muscle weight normalized for body weight. CL did not reduce the decrease in soleus P-o or mass after HS in adult rats. CL failed to reduce the loss of plantaris weight (-20%) and P-o (-46%) in senescent rats after HS. Our data support the conclusion that physiological levelsof CL do not improve fast muscle atrophy and only modestly reduce slow muscle atrophy, and, therefore, it is largely an ineffective countermeasure for preventing muscle wasting from HS in senescent rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:49:16