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Titolo:
Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction
Autore:
Maeda, K; Tsutamoto, T; Wada, A; Mabuchi, N; Hyashi, M; Hisanaga, T; Kamijo, T; Kinoshita, M;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 1, Otsu, Shiga 5202192, Japan Chugai Pharmaceut Co Ltd, Prod Planning Dept, Tokyo 1048301, Japan Chugai Pharmaceut Co Ltd Tokyo Japan 1048301 Dept, Tokyo 1048301, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 89, anno: 2000,
pagine: 458 - 464
SICI:
8750-7587(200008)89:2<458:ISOANP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; LEFT-VENTRICULAR DYSFUNCTION; END-DIASTOLIC PRESSURE; PLASMA-LEVELS; GUANYLATE-CYCLASE; CARDIAC HORMONE; A-TYPE; DOGS; RESPONSES; INFUSION;
Keywords:
cardiac natriuretic peptides; ischemia; pulmonary capillary wedge pressure; acute heart failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutamoto, T Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192,Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 a 5202192, Japan
Citazione:
K. Maeda et al., "Insufficient secretion of atrial natriuretic peptide at acute phase of myocardial infarction", J APP PHYSL, 89(2), 2000, pp. 458-464

Abstract

To investigate the secretion of the plasma levels of atrial natriuretic peptide (ANP) in patients with acute myocardial infarction (AMI), we evaluated the relationship between plasma levels of ANP and pulmonary capillary wedge pressure (PCWP) in 45 consecutive patients during the acute phase of AMI(similar to 12 h after the attack) (group 1) and compared data with those obtained after 1 mo (group 2). In both groups 1 and 2, plasma ANP levels significantly correlated with PCWP. The slope of the linear regression line between the PCWP and ANP in group 1 was significantly lower, by about one-third, than that in group 2. In addition, we examined changes in ANP levels and left ventricular end-diastolic pressure (LVEDP) over 180 min after AMI induced by injection of microspheres into the left coronary arteries of three dogs. The LVEDP and ANP levels 30 min after AMI were significantly higherthan those before; however, despite the persistent high LVEDP during the 180 min after AMI, ANP levels decreased gradually and significantly to 63% of the peak level at 150 min. These findings suggest that the secretion of ANP during the acute phase of myocardial infarction may be insufficient relative to the chronic phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:28:37