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Titolo:
PRIMING OF THE ANTITUMOR RESPONSE PROMOTES EFFICACY OF INTERLEUKIN-2 THERAPY
Autore:
EVERSE LA; BERNSEN MR; DULLENS HFJ; DENOTTER W;
Indirizzi:
UNIV UTRECHT,DEPT FUNCT MORPHOL,YALELAAN 1 NL-3584 CL UTRECHT NETHERLANDS H04312 ACAD HOSP UTRECHT,DEPT PATHOL NL-3508 GA UTRECHT NETHERLANDS
Titolo Testata:
Cancer immunology and immunotherapy
fascicolo: 4, volume: 44, anno: 1997,
pagine: 221 - 229
SICI:
0340-7004(1997)44:4<221:POTARP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE SPECIFIC IMMUNOTHERAPY; T-CELLS; ADJUVANT IMMUNOTHERAPY; ESTABLISHED TUMORS; MELANOMA; CANCER; REGRESSION; CARCINOMA; ANTIGENS; IMMUNITY;
Keywords:
IMMUNIZATION; INTERLEUKIN-2; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Everse et al., "PRIMING OF THE ANTITUMOR RESPONSE PROMOTES EFFICACY OF INTERLEUKIN-2 THERAPY", Cancer immunology and immunotherapy, 44(4), 1997, pp. 221-229

Abstract

We have studied the effect of active specific immunization (ASI) on the antitumor response induced by locoregional, low-dose interleukin-2 (IL-2) therapy. On day O, mice were injected i.p. with viable, syngeneic tumor cells and with irradiated tumor cells (ASI). Low-dose IL-2 treatment was given i.p. for 5 consecutive days. ASI led to extended survival in two out of seven models tested. In these two models, enhancedefficacy was observed when both ASI and IL-2 were administered. In the five models in which ASI had no therapeutic value, ASI+IL-2 treatment was no more effective than IL-2 therapy. In the SL2 lymphoma model, use of ASI prior to IL-2 therapy given as early as days 1-5 led to at least 60% cure, whereas IL-2 therapy without ASI was only effective when administered after day 9. In the P815 mastocytoma model, however, ASI, IL-2, and the combination caused negative (suppressive) effects when administered on days 6-10. IL-2 administered on days 6-10 was therapeutically effective in this model when mice were treated with cyclophosphamide on day 6. In both the SL2 and the P815 tumor models, cured mice were specifically immune. The positive and negative effects observed were not due to the increased number of cells injected (non-specific inflammation) nor to possible antigenic alteration of the ASI cells by irradiation, as ASI with fragmented tumor eels was also effective in inducing synergy. Investigations into the underlying mechanism indicated that CD4(+) cells play an important role. In total, the results indicate that ASI may be a good supplement to locoregional IL-2 treatment if care is taken to alleviate immunosuppressive activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:57:29