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Titolo:
Influences of everninomicin, vancomycin and teicoplanin on chemical mediator release from rat peritoneal mast cells
Autore:
Sugimoto, Y; Iba, Y; Utsugi, K; Kamei, C;
Indirizzi:
Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 ept Pharmacol, Okayama 7008530, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 4, volume: 83, anno: 2000,
pagine: 300 - 305
SICI:
0021-5198(200008)83:4<300:IOEVAT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-MAN SYNDROME; INDUCED HISTAMINE-RELEASE; ANAPHYLACTOID REACTIONS; CALCIUM; INFECTIONS;
Keywords:
everninomicin; vancomycin; teicoplanin; histamine release; prostaglandin D-2 release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kamei, C Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, 2-5-1 Shikata Cho, Okayama 7008530, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008530 8530, Japan
Citazione:
Y. Sugimoto et al., "Influences of everninomicin, vancomycin and teicoplanin on chemical mediator release from rat peritoneal mast cells", JPN J PHARM, 83(4), 2000, pp. 300-305

Abstract

We examined influences of certain antibiotics on the release of chemical mediators from isolated rat peritoneal mast cells in vitro. Isolated peritoneal mast cells were obtained from male Wistar strain rats. Everninomicin (0.06 - 1.2 mg/ml), vancomycin (0.05 - 1.0 mg/ml), teicoplanin (0.07 - 1.4 mg/ml) and concanavalin A (0.01 mg/ml) were used. Isolated mast cells were incubated in the presence of various concentrations of the test compound at 37 degrees C for 10 min. Histamine contents of the supernatant and cell pellet were measured by an automated fluorometric method. Prostaglandin D-2 (PGD(2)) contents of the supernatant were determined by enzyme immunoassay. Everninomicin (0.06-1.2 mg/ml) had no influence on histamine and PGD2 releasefrom mast cells. On the other hand, vancomycin significantly released bothhistamine (0.5 and 1.0 mg/ml) and PGD(2) (1.0 mg/ml) from mast cells, but vancomycin did not affect concanavalin A-induced histamine and PGD(2) release. Teicoplanin (more than 0.07 mg/ml) significantly stimulated histamine and PGD(2) release from mast cells and it also significantly potentiated concanavalin A-induced histamine and PGD:! release. These results suggest thateverninomicin causes no chemical mediator release from mast cells, different from vancomycin and teicoplanin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:08:21