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Titolo:
Radiotherapy and radical surgery for treatment of patients with bulky stage IB and II cervical carcinoma
Autore:
Morice, P; Haie-Meder, C; Rey, A; Pautier, P; Lhomme, C; Gerbaulet, A; Duvillard, P; Castaigne, D;
Indirizzi:
Inst Gustave Roussy, Dept Gynecol Surg, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Radiotherapy, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Biostat, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Oncol, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Inst Gustave Roussy, Dept Pathol, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
fascicolo: 3, volume: 10, anno: 2000,
pagine: 239 - 246
SICI:
1048-891X(200005/06)10:3<239:RARSFT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTACT UTERINE CERVIX; RADIATION-THERAPY; EXTRAFASCIAL HYSTERECTOMY; NEOADJUVANT CHEMOTHERAPY; PROGNOSTIC FACTOR; PELVIC RADIATION; RANDOMIZED TRIAL; LYMPH-NODES; CANCER; CISPLATIN;
Keywords:
bulky tumor; carcinoma of the cervix; lymphadenectomy; prognostic factors; radical hysterectomy; radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Morice, P Inst Gustave Roussy, Dept Gynecol Surg, 39 Rue Camille Desmoulins, F-94805Villejuif, France Inst Gustave Roussy 39 Rue Camille Desmoulins Villejuif France F-94805
Citazione:
P. Morice et al., "Radiotherapy and radical surgery for treatment of patients with bulky stage IB and II cervical carcinoma", INT J GYN C, 10(3), 2000, pp. 239-246

Abstract

The aim of this study was to evaluate prognostic factors and to study combination radiotherapy-surgery as treatment for patients with bulky stage Ib and II cervical carcinoma. From 1985 to 1994, 187 patients with cervical cancer greater than or equal to 4 cm, were treated by combined radiation therapy and radical surgery including systematic para-aortic lymphadenectomy. Complications were observed in 34 (18%) patients. In a multivariate analysis, young age, tumor size less than 5 cm, metastatic nodes with capsular rupture, and bilateral nodes were independent prognostic factors. Overall survival at 3 years was 85%, 56%, and 40% in patients with negative nodes, positive pelvic nodes, and positive para-aortic nodes, respectively (P < 0.001). These results confirm the prognostic significance of young age, tumor size, and nodal involvement. Radical surgery combined with radiotherapy is feasible, with an acceptable rate of complications and yields satisfactory survival results in patients with bulky stage IB and II cervical carcinoma. Recent randomized published studies have demonstrated that concomitant chemotherapy and radiotherapy should be the gold standard in this setting. The role of surgery is questioned.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:59:43