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Titolo:
Monocyte inflammatory protein-1 alpha facilitates priming of CD8(+) T cellresponses to exogenous viral antigen
Autore:
Flesch, IEA; Stober, D; Schirmbeck, R; Reimann, J;
Indirizzi:
Univ Ulm, Dept Med Microbiol & Immunol, D-89081 Ulm, Germany Univ Ulm Ulm Germany D-89081 d Microbiol & Immunol, D-89081 Ulm, Germany
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 9, volume: 12, anno: 2000,
pagine: 1365 - 1370
SICI:
0953-8178(200009)12:9<1365:MIPAFP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
B SURFACE-ANTIGEN; DENDRITIC CELLS; CHEMOKINE RECEPTORS; IN-VIVO; LYMPHOID ORGANS; LYMPHOCYTES; MATURATION; IMMUNITY; NAIVE; MICE;
Keywords:
chemokines; cytotoxic T lymphocyte priming; dendritic cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Reimann, J Univ Ulm, Dept Med Microbiol & Immunol, Helmholtzstr 8-1, D-89081 Ulm, Germany Univ Ulm Helmholtzstr 8-1 Ulm Germany D-89081 081 Ulm, Germany
Citazione:
I.E.A. Flesch et al., "Monocyte inflammatory protein-1 alpha facilitates priming of CD8(+) T cellresponses to exogenous viral antigen", INT IMMUNOL, 12(9), 2000, pp. 1365-1370

Abstract

Dendritic cells (DC) derived from bone marrow precursors of BALB/c or C57BL/6 mice in low-serum cultures supplemented with granulocyte macrophage colony stimulating factor and Fits ligand were pulsed in vitro with hepatitis B surface antigen (HBsAg) particles, DC processed exogenous HBsAg and presented its MHC class I-binding epitopes to cytotoxic T lymphocytes (CTL). This specific and restricted interaction of DC with CTL stimulated release of IFN-gamma and macrophage inflammatory protein (MIP)-1 alpha from the responding CTL, MIP-1 alpha enhanced the survival of DC in vitro but did not induce proliferation, Furthermore, co-delivery of MIP-1 alpha facilitated CTL priming in vivo to exogenous HBsAg in low responder C57BL/6 (H-2(b)) mice: asingle injection of a low dose of HBsAg particles (without further adjuvants) successfully primed K-b-restricted CTL responses to HBsAg only when theexogenous antigen was co-delivered with 100 ng MIP-1 alpha. These in vitroand In vivo data point to an important role of MIP-1 alpha in the DC-dependent priming of CTL to exogenous viral antigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:57:09