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Titolo:
Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism
Autore:
Thomas, GN; Tomlinson, B; Critchley, JAJH;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Div Clin Pharmacol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 36, anno: 2000,
pagine: 177 - 182
SICI:
0194-911X(200008)36:2<177:MOBPAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; FREELY MOVING RATS; RELEASE; REWARD; RFLP; DRD2; STIMULATION; INHIBITION; ACTIVATION; BINDING;
Keywords:
body mass index; race; dopamine; receptors, dopamine; genetics; hypertension, obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, GN Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Div Clin Pharmacol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China China
Citazione:
G.N. Thomas et al., "Modulation of blood pressure and obesity with the dopamine D2 receptor gene TaqI polymorphism", HYPERTENSIO, 36(2), 2000, pp. 177-182

Abstract

Pharmacological data suggest that obesity and blood pressure (BP) may be modulated through the dopamine D2 receptor (DD2R), which may represent an underlying mechanism that links these conditions. A TaqI polymorphism near the DD2R gene has been associated with indices of obesity in white populations. We compared anthropometric and fasting plasma biochemical parameters between 209 nondiabetic hypertensive and 174 gender-matched normotensive Chinese subjects. The hyperintensives had increased dyslipidemia, increased fasting plasma glucose concentrations, and a greater degree of obesity. The A1 and A2 alleles of the DD2R gene TaqI polymorphism were identified with a polymerase chain reaction-based restriction fragment length polymorphism protocol. The Al allele frequency was decreased in the hypertensives (42.0%) compared with the control subjects (52.0%, P=0.006), and genotype frequencieswere different (P=0.05) between the 2 groups. In the combined population (n=383), systolic, diastolic, and mean arterial BPs were 6, 5, and 6 mm Hg lower, respectively, in subjects with the A1A1 genotype relative to the A2A2genotype (all P<0.05), whereas skinfold thickness was increased at the iliac (P<0.001) and triceps (P<0.03) sites but not at the biceps or subscapular sites. Furthermore, this DD2R gene polymorphism was shown to be a significant independent predictor of diastolic BP and iliac and triceps skinfold thicknesses (all P<0.03). These contrasting associations of the DD2R TaqI polymorphism A1 allele with lower BP but increased markers of "gynoidal" or peripheral subcutaneous obesity (iliac and triceps skinfold thicknesses) in our Chinese population may provide some insight into the underlying relationship between BP and body fat distribution, but the exact nature of this link remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:43:36