Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
METABOTROPIC GLUTAMATE-RECEPTOR MEDIATED LONG-TERM DEPRESSION IN DEVELOPING HIPPOCAMPUS
Autore:
OVERSTREET LS; PASTERNAK JF; COLLEY PA; SLATER NT; TROMMER BL;
Indirizzi:
EVANSTON HOSP CORP,DIV NEUROL,DEPT PEDIAT,2650 RIDGE AVE EVANSTON IL 60201 EVANSTON HOSP CORP,DIV NEUROL,DEPT PEDIAT EVANSTON IL 60201 NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT PEDIAT CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT NEUROL CHICAGO IL 60611
Titolo Testata:
Neuropharmacology
fascicolo: 6, volume: 36, anno: 1997,
pagine: 831 - 844
SICI:
0028-3908(1997)36:6<831:MGMLDI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL RAT HIPPOCAMPUS; CEREBELLAR GRANULE CELLS; MGLUR1 MUTANT MICE; SIGNAL-TRANSDUCTION; AREA CA1; MOLECULAR CHARACTERIZATION; DENTATE GYRUS; MESSENGER-RNA; SYNAPTIC TRANSMISSION; NEURONAL MIGRATION;
Keywords:
HIPPOCAMPUS; AREA CA1; SYNAPTIC PLASTICITY; N-METHYL-D-ASPARTATE RECEPTOR (NMDAR); MGLUR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Overstreet et al., "METABOTROPIC GLUTAMATE-RECEPTOR MEDIATED LONG-TERM DEPRESSION IN DEVELOPING HIPPOCAMPUS", Neuropharmacology, 36(6), 1997, pp. 831-844

Abstract

The effects of bath application of the metabotropic glutamate receptor (mGluR) agonist 1S,3R-1-aminocyclopentane-1 ,3-dicarboxylic acid (ACPD, 10 mu M) were studied at the Schaffer collateral-CA1 synapse in hippocampal slices from rats of 8-33 days postnatal age. In immature animals (8-12 days) ACPD induced a biphasic response characterized by an acute decrease in field EPSP slope (similar to 50-60% of baseline) in the presence of the agonist, followed by long-term depression (LTD, similar to 75-80% of baseline) after washout. In animals older than 20 days, ACPD induced a slow onset potentiation or minimal change. Both the acute depression and LTD were blocked by the mGluR antagonist alpha-methyl-4-carboxyphenyl glycine (MCPG). ACPD-induced LTD was blocked bythe N-methyl-D-aspartate receptor (NMDAR) antagonists D(-)-2-amino-5 phosphopentanoic acid (APS) and dizocilpine maleate (MK-801), and by ethanol. Glutamic pyruvic transaminase, an enzyme that selectively metabolizes endogenous extracellular glutamate, also blocked LTD suggesting that the requisite NMDA currents were tonically activated by extracellular rather than synaptically released glutamate. ACPD-induced LTD was blocked by staurosporine, indicating a requirement for serine-threonine kinase activation, and was unaffected by the L-type voltage sensitive calcium channel blocker nitrendipine and the A1 adenosine receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT). Because mGluR-mediated LTD was observed only in immature CA1, mGluRs may play a role in hippocampal development, perhaps by contributing to synapse pruningin a temporally restricted fashion. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:57:00