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Titolo:
EVIDENCE TO SUGGEST THAT AGONIST MODULATION OF HYPERLOCOMOTION IS VIAPOSTSYNAPTIC DOPAMINE D-2 OF D-3 RECEPTORS
Autore:
THORN L; ASHMEADE TE; STOREY VJ; ROUTLEDGE C; REAVILL C;
Indirizzi:
SMITHKLINE BEECHAM,NEW FRONTIERS SCI PK,3RD AVE HARLOW CM19 5AW ESSEXENGLAND
Titolo Testata:
Neuropharmacology
fascicolo: 6, volume: 36, anno: 1997,
pagine: 787 - 792
SICI:
0028-3908(1997)36:6<787:ETSTAM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT IN-VIVO; MESSENGER-RNA; SELECTIVE ANTAGONIST; LOCOMOTOR-ACTIVITY; NUCLEUS ACCUMBENS; HUMAN BRAIN; SUPPRESSION; ACTIVATION; 7-OH-DPAT; LIGAND;
Keywords:
DOPAMINE; DOPAMINE D-2 RECEPTOR; DOPAMINE D-3 RECEPTOR; QUINELORANE; AMPHETAMINE; LOCOMOTOR ACTIVITY; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L. Thorn et al., "EVIDENCE TO SUGGEST THAT AGONIST MODULATION OF HYPERLOCOMOTION IS VIAPOSTSYNAPTIC DOPAMINE D-2 OF D-3 RECEPTORS", Neuropharmacology, 36(6), 1997, pp. 787-792

Abstract

It has been suggested that a sub-population of dopamine D-3 receptorsis located pre-synaptically and these serve as autoreceptors in dopamine projection areas such as the nucleus accumbens/ventral striatum. To study further the physiological role and synaptic location of the dopamine D-3 receptor, we have investigated the in vivo effect of the D-3/D-2 receptor agonist quinelorane on amphetamine-induced hyperactivity and extracellular dopamine release from the nucleus accumbens of theconscious rat. Amphetamine increased dopamine release to 202 +/- 34% of pre-injection control values, but quinelorane at 2.5 mu g/kg, a dose which effectively blocked amphetamine-induced hyperlocomotion, had no significant effect on amphetamine-induced dopamine release. These data suggest that hyperlocomotion is mediated via postsynaptic rather than pre-synaptic dopamine receptors. Since quinelorane has significant affinity for the dopamine D-3 receptor, these effects may be via post-synaptic D-3 receptors; however, D-2 receptor effects cannot be disregarded. In summary, these data indicate that the quinelorane effect on amphetamine-stimulated hyperlocomotion is not mediated via D-3 or D-2 autoreceptors, but rather a population of receptors located post-synaptically, which appear to mediate the inhibition of rat locomotor activity. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 12:55:04