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Titolo:
[H-3] RACLOPRIDE BINDING TO BRAIN-TISSUE FROM SUBJECTS WITH SCHIZOPHRENIA - METHODOLOGICAL ASPECTS
Autore:
DEAN B; PAVEY G; OPESKIN K;
Indirizzi:
MENTAL HLTH RES INST,REBECCA L COOPER RES LABS,LOCKED BAG 11 PARKVILLE VIC 3052 AUSTRALIA VICTORIAN INST FORENS MED S BANK VIC AUSTRALIA
Titolo Testata:
Neuropharmacology
fascicolo: 6, volume: 36, anno: 1997,
pagine: 779 - 786
SICI:
0028-3908(1997)36:6<779:[RBTBF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D-4 RECEPTORS; POSITRON EMISSION TOMOGRAPHY; H-3 RACLOPRIDE BINDING; D4 RECEPTORS; HIGH-AFFINITY; UPTAKE SITES; RAT-BRAIN; D2; DRUG; NEMONAPRIDE;
Keywords:
SCHIZOPHRENIA; DOPAMINE-D-2 RECEPTORS; HUMAN BRAIN; CAUDATE-PUTAMEN; RACLOPRIDE BINDING; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
B. Dean et al., "[H-3] RACLOPRIDE BINDING TO BRAIN-TISSUE FROM SUBJECTS WITH SCHIZOPHRENIA - METHODOLOGICAL ASPECTS", Neuropharmacology, 36(6), 1997, pp. 779-786

Abstract

The binding of [H-3]raclopride to particulate membrane and frozen sections (with quantitative autoradiography) from the caudate-putamen, obtained at autopsy from schizophrenic and non-schizophrenic subjects, was measured. The affinity of [H-3]raclopride to particulate membrane was significantly decreased in the schizophrenic compared to non-schizophrenic subjects. The density of [H-3]raclopride binding to tissue from subjects with schizophrenia was increased, unchanged or decreased depending on the methodology used. Finally, there was an age-dependent decrease in [H-3]raclopride binding in the frozen sections from the caudate-putamen of the non-schizophrenic subjects. This age-dependent decrease was not apparent using particulate membrane from schizophrenic or non-schizophrenic subjects or tissue sections from the schizophrenicsubjects. We conclude that the binding of [H-3]raclopride is dependent on methodology and therefore data from in vitro and in vivo studies using this drug should be interpreted with caution. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:14:23