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Titolo:
Phosphorylcholine-containing N-glycans of Trichinella spiralis: identification of multiantennary lacdiNAc structures
Autore:
Morelle, W; Haslam, SM; Olivier, V; Appleton, JA; Morris, HR; Dell, A;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AY,England Univ London Imperial Coll Sci Technol & Med London England SW7 2AY gland Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USACornell Univ Ithaca NY USA 14853 icrobiol & Immunol, Ithaca, NY 14853 USA
Titolo Testata:
GLYCOBIOLOGY
fascicolo: 9, volume: 10, anno: 2000,
pagine: 941 - 950
SICI:
0959-6658(200009)10:9<941:PNOTSI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCRETORY-SECRETORY PRODUCT; ACANTHOCHEILONEMA-VITEAE; RAPID EXPULSION; LINKED OLIGOSACCHARIDES; SUCKLING RATS; MONOCLONAL-ANTIBODIES; PARASITIC NEMATODE; BRUGIA-MALAYI; ASCARIS-SUUM; STAGE LARVAE;
Keywords:
fast atom bombardment mass spectrometry; nematode glycosylation; phosphorylcholine containing carbohydrates; structure analysis; Trichinella spiralis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Dell, A Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AY,England Univ London Imperial Coll Sci Technol & Med London England SW7 2AY
Citazione:
W. Morelle et al., "Phosphorylcholine-containing N-glycans of Trichinella spiralis: identification of multiantennary lacdiNAc structures", GLYCOBIOLOG, 10(9), 2000, pp. 941-950

Abstract

Although the presence of phosphorylcholine (PC) in Trichinella spiralis iswell established, the precise structure of the PC-bearing molecules is notknown. In this paper, we report structural studies of N-glycans released from T.spiralis affinity-purified antigens by peptide N-glycosidase F. Threeclasses of N-glycan structures were observed: high mannose type structures; those which had been fully trimmed to the trimannosyl core and were sub-stoichiometrically fucosylated; and those with a trimannosyl core, with and without core fucosylation, carrying between one and eight N-acetylhexosamine residues. Of the three classes of glycans, only the last was found to be substituted with detectable levels of phosphorylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:57:28